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Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.

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Title: Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.
Authors: Tong N; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States., Wong-Roushar J; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Wallace-Povirk A; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States., Shah Y; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States., Nyman MC; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Katinas JM; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Schneider M; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States., O'Connor C; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States., Bao X; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States., Kim S; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States., Li J; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States., Hou Z; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States., Matherly LH; Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.; Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States., Dann CE 3rd; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Gangjee A; Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, United States.
Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2023 Apr 26; Vol. 6 (5), pp. 748-770. Date of Electronic Publication: 2023 Apr 26 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE
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