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Conformational Dynamics of the Activated GLP-1 Receptor-Gs Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling.

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Title: Conformational Dynamics of the Activated GLP-1 Receptor-Gs Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling.
Authors: Yuan S; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Xia L; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Wang C; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Wu F; Structure Therapeutics, South San Francisco, California 94080, United States., Zhang B; iHuman Institute, ShanghaiTech University, Shanghai 201210, China., Pan C; National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China., Fan Z; Biocreater (WuHan) Biotechnology Co., Ltd, Wuhan 430075, China., Lei X; Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China., Stevens RC; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Structure Therapeutics, South San Francisco, California 94080, United States., Sali A; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, California 94143, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94143, United States.; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States., Sun L; iHuman Institute, ShanghaiTech University, Shanghai 201210, China., Shui W; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Source: ACS central science [ACS Cent Sci] 2023 Apr 24; Vol. 9 (5), pp. 992-1007. Date of Electronic Publication: 2023 Apr 24 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: eCollection Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yuan+S%22">Yuan S</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Xia+L%22">Xia L</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; Structure Therapeutics, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Pan+C%22">Pan C</searchLink>; National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Fan+Z%22">Fan Z</searchLink>; Biocreater (WuHan) Biotechnology Co., Ltd, Wuhan 430075, China.<br /><searchLink fieldCode="AU" term="%22Lei+X%22">Lei X</searchLink>; Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.<br /><searchLink fieldCode="AU" term="%22Stevens+RC%22">Stevens RC</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Structure Therapeutics, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Sali+A%22">Sali A</searchLink>; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, California 94143, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94143, United States.; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.<br /><searchLink fieldCode="AU" term="%22Shui+W%22">Shui W</searchLink>; iHuman Institute, ShanghaiTech University, Shanghai 201210, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
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