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Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C.

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Title: Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C.
Authors: Hu C; Mayo Clinic, Rochester, Minnesota., Nagaraj AB; Mayo Clinic, Rochester, Minnesota., Shimelis H; Mayo Clinic, Rochester, Minnesota., Montalban G; CHU de Quebec-Université Laval Research Center, Université Laval, Quebec City, Quebec, Canada., Lee KY; Mayo Clinic, Rochester, Minnesota., Huang H; Mayo Clinic, Rochester, Minnesota., Lumby CA; Mayo Clinic, Rochester, Minnesota., Na J; Mayo Clinic, Rochester, Minnesota., Susswein LR; GeneDx, Gaithersburg, Maryland., Roberts ME; GeneDx, Gaithersburg, Maryland., Marshall ML; GeneDx, Gaithersburg, Maryland., Hiraki S; GeneDx, Gaithersburg, Maryland., LaDuca H; Ambry Genetics, Aliso Viejo, California., Chao E; Ambry Genetics, Aliso Viejo, California., Yussuf A; Ambry Genetics, Aliso Viejo, California., Pesaran T; Ambry Genetics, Aliso Viejo, California., Neuhausen SL; Beckman Research Institute of City of Hope, Duarte, California., Haiman CA; Keck School of Medicine, University of Southern California, Los Angeles, California., Kraft P; T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Lindstrom S; Department of Epidemiology, University of Washington, Seattle, Washington., Palmer JR; Slone Epidemiology Center at Boston University, Boston, Massachusetts., Teras LR; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia., Vachon CM; Mayo Clinic, Rochester, Minnesota., Yao S; Roswell Park Comprehensive Cancer Center, Buffalo, New York., Ong I; University of Wisconsin-Madison, Madison, Wisconsin., Nathanson KL; University of Pennsylvania, Philadelphia, Pennsylvania., Weitzel JN; Latin American School of Oncology, Sierra Madre, California., Boddicker N; Mayo Clinic, Rochester, Minnesota., Gnanaolivu R; Mayo Clinic, Rochester, Minnesota., Polley EC; University of Chicago, Chicago, Illinois., Mer G; Mayo Clinic, Rochester, Minnesota., Cui G; Mayo Clinic, Rochester, Minnesota., Karam R; Ambry Genetics, Aliso Viejo, California., Richardson ME; Ambry Genetics, Aliso Viejo, California., Domchek SM; University of Pennsylvania, Philadelphia, Pennsylvania., Yadav S; Mayo Clinic, Rochester, Minnesota., Hruska KS; GeneDx, Gaithersburg, Maryland., Dolinsky J; Ambry Genetics, Aliso Viejo, California., Weroha SJ; Mayo Clinic, Rochester, Minnesota., Hart SN; Mayo Clinic, Rochester, Minnesota., Simard J; CHU de Quebec-Université Laval Research Center, Université Laval, Quebec City, Quebec, Canada., Masson JY; CHU de Quebec-Université Laval Research Center, Université Laval, Quebec City, Quebec, Canada., Pang YP; Mayo Clinic, Rochester, Minnesota., Couch FJ; Mayo Clinic, Rochester, Minnesota.
Source: Cancer research [Cancer Res] 2023 Aug 01; Vol. 83 (15), pp. 2557-2571.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C.
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