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A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.

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Title: A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.
Authors: Glunk V; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Laber S; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA., Sinnott-Armstrong N; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Herbold Computational Biology Program, Publich Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Sobreira DR; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Strobel SM; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA., Batista TM; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kubitz P; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Moud BN; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Ebert H; Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany., Huang Y; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Brandl B; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Garbo G; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA., Honecker J; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Stirling DR; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Abdennur N; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Calabuig-Navarro V; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany., Skurk T; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Ocvirk S; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Intestinal Microbiology Research Group, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Stemmer K; Molecular Cell Biology, Institute for Theoretical Medicine, University of Augsburg, Augsburg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Cimini BA; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dankel SN; Department of Clinical Science, University of Bergen, Bergen, Norway., Lindgren CM; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Hauner H; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Nobrega MA; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Claussnitzer M; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA. melina@broadinstitute.org.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. melina@broadinstitute.org.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. melina@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. melina@broadinstitute.org.
Source: Nature metabolism [Nat Metab] 2023 May; Vol. 5 (5), pp. 861-879. Date of Electronic Publication: 2023 May 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.
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  Data: <searchLink fieldCode="AU" term="%22Glunk+V%22">Glunk V</searchLink>; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Laber+S%22">Laber S</searchLink>; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sinnott-Armstrong+N%22">Sinnott-Armstrong N</searchLink>; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Herbold Computational Biology Program, Publich Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Sobreira+DR%22">Sobreira DR</searchLink>; Department of Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Strobel+SM%22">Strobel SM</searchLink>; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Batista+TM%22">Batista TM</searchLink>; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kubitz+P%22">Kubitz P</searchLink>; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; 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Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brandl+B%22">Brandl B</searchLink>; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Garbo+G%22">Garbo G</searchLink>; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Honecker+J%22">Honecker J</searchLink>; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Stirling+DR%22">Stirling DR</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Abdennur+N%22">Abdennur N</searchLink>; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Calabuig-Navarro+V%22">Calabuig-Navarro V</searchLink>; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Skurk+T%22">Skurk T</searchLink>; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Ocvirk+S%22">Ocvirk S</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Intestinal Microbiology Research Group, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Stemmer+K%22">Stemmer K</searchLink>; Molecular Cell Biology, Institute for Theoretical Medicine, University of Augsburg, Augsburg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cimini+BA%22">Cimini BA</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carpenter+AE%22">Carpenter AE</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dankel+SN%22">Dankel SN</searchLink>; Department of Clinical Science, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Lindgren+CM%22">Lindgren CM</searchLink>; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hauner+H%22">Hauner H</searchLink>; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Nobrega+MA%22">Nobrega MA</searchLink>; Department of Human Genetics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Claussnitzer+M%22">Claussnitzer M</searchLink>; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA. melina@broadinstitute.org.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. melina@broadinstitute.org.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. melina@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. melina@broadinstitute.org.
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