A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.
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| Title: | A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. |
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| Authors: | Glunk V; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Laber S; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA., Sinnott-Armstrong N; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA.; Herbold Computational Biology Program, Publich Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Sobreira DR; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Strobel SM; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA., Batista TM; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kubitz P; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Moud BN; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Ebert H; Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany., Huang Y; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Brandl B; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Garbo G; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA., Honecker J; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Stirling DR; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Abdennur N; Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Calabuig-Navarro V; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Institute of Nutritional Sciences, University of Hohenheim, Stuttgart, Germany., Skurk T; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Ocvirk S; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Intestinal Microbiology Research Group, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Stemmer K; Molecular Cell Biology, Institute for Theoretical Medicine, University of Augsburg, Augsburg, Germany.; Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Cimini BA; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dankel SN; Department of Clinical Science, University of Bergen, Bergen, Norway., Lindgren CM; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Hauner H; Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.; ZIEL Institute for Food & Health, Else Kröner-Fresenius-Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany., Nobrega MA; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Claussnitzer M; Broad Institute of MIT and Harvard, Medical and Population Genetics Program & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA. melina@broadinstitute.org.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. melina@broadinstitute.org.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. melina@broadinstitute.org.; Department of Medicine, Harvard Medical School, Boston, MA, USA. melina@broadinstitute.org. |
| Source: | Nature metabolism [Nat Metab] 2023 May; Vol. 5 (5), pp. 861-879. Date of Electronic Publication: 2023 May 30. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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