Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.

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Title: Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.
Authors: Colombo S; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Reddy HP; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India., Petri S; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Williams DJ; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Shalomov B; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel., Dhindsa RS; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Gelfman S; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Krizay D; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Bera AK; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India., Yang M; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Mouse NeuroBehavior Core Facility, Columbia University Irving Medical Center, New York, NY, United States., Peng Y; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States., Makinson CD; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neuroscience, Columbia University, New York, NY, United States., Boland MJ; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States., Frankel WN; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, United States., Goldstein DB; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, United States., Dascal N; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Source: Frontiers in cellular neuroscience [Front Cell Neurosci] 2023 May 18; Vol. 17, pp. 1175895. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1662-5102
DOI:10.3389/fncel.2023.1175895