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Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.

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Title: Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.
Authors: Colombo S; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Reddy HP; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India., Petri S; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Williams DJ; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Shalomov B; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel., Dhindsa RS; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Gelfman S; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Krizay D; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States., Bera AK; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India., Yang M; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Mouse NeuroBehavior Core Facility, Columbia University Irving Medical Center, New York, NY, United States., Peng Y; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States., Makinson CD; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neuroscience, Columbia University, New York, NY, United States., Boland MJ; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States., Frankel WN; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, United States., Goldstein DB; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, United States., Dascal N; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Source: Frontiers in cellular neuroscience [Front Cell Neurosci] 2023 May 18; Vol. 17, pp. 1175895. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
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  Data: Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Colombo+S%22">Colombo S</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Reddy+HP%22">Reddy HP</searchLink>; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.<br /><searchLink fieldCode="AU" term="%22Petri+S%22">Petri S</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Williams+DJ%22">Williams DJ</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Shalomov+B%22">Shalomov B</searchLink>; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Dhindsa+RS%22">Dhindsa RS</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Gelfman+S%22">Gelfman S</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Krizay+D%22">Krizay D</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Bera+AK%22">Bera AK</searchLink>; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Mouse NeuroBehavior Core Facility, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Peng+Y%22">Peng Y</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Makinson+CD%22">Makinson CD</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neuroscience, Columbia University, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Boland+MJ%22">Boland MJ</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Frankel+WN%22">Frankel WN</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Goldstein+DB%22">Goldstein DB</searchLink>; Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Dascal+N%22">Dascal N</searchLink>; Department of Physiology and Pharmacology, School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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  Data: <searchLink fieldCode="JN" term="%22101477935%22">Frontiers in cellular neuroscience</searchLink> [Front Cell Neurosci] 2023 May 18; Vol. 17, pp. 1175895. <i>Date of Electronic Publication: </i>2023 May 18 (<i>Print Publication: </i>2023).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101477935 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1662-5102 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216625102%22">16625102 </searchLink><i>NLM ISO Abbreviation: </i>Front Cell Neurosci <i>Subsets: </i>PubMed not MEDLINE
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