Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma.

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Title: Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma.
Authors: Wang X; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Kutschat AP; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Aggrey-Fynn J; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Hamdan FH; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Graham RP; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota., Wixom AQ; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota., Souto Y; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Ladigan-Badura S; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany., Yonkus JA; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota., Abdelrahman AM; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota., Alva-Ruiz R; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota., Gaedcke J; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, 37075 Göttingen, Germany., Ströbel P; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, 37075 Göttingen, Germany.; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany., Kosinsky RL; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Wegwitz F; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany., Hermann P; Department of Internal Medicine I, Ulm University, Germany., Truty MJ; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota., Siveke JT; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Hahn SA; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany., Hessmann E; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, 37075 Göttingen, Germany.; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany., Johnsen SA; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Najafova Z; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.
Source: Molecular cancer research : MCR [Mol Cancer Res] 2023 Sep 01; Vol. 21 (9), pp. 881-891.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE
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  Data: Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kutschat+AP%22">Kutschat AP</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Aggrey-Fynn+J%22">Aggrey-Fynn J</searchLink>; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Hamdan+FH%22">Hamdan FH</searchLink>; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Graham+RP%22">Graham RP</searchLink>; Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Wixom+AQ%22">Wixom AQ</searchLink>; Gene Regulatory Mechanisms and Molecular Epigenetics Lab, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Souto+Y%22">Souto Y</searchLink>; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Ladigan-Badura+S%22">Ladigan-Badura S</searchLink>; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Yonkus+JA%22">Yonkus JA</searchLink>; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Abdelrahman+AM%22">Abdelrahman AM</searchLink>; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Alva-Ruiz+R%22">Alva-Ruiz R</searchLink>; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Gaedcke+J%22">Gaedcke J</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, 37075 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ströbel+P%22">Ströbel P</searchLink>; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, 37075 Göttingen, Germany.; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kosinsky+RL%22">Kosinsky RL</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Wegwitz+F%22">Wegwitz F</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+P%22">Hermann P</searchLink>; Department of Internal Medicine I, Ulm University, Germany.<br /><searchLink fieldCode="AU" term="%22Truty+MJ%22">Truty MJ</searchLink>; Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Siveke+JT%22">Siveke JT</searchLink>; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner site University Hospital Essen, and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hahn+SA%22">Hahn SA</searchLink>; Department of Molecular Gastrointestinal Oncology, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Hessmann+E%22">Hessmann E</searchLink>; Clinical Research Unit 5002, KFO5002, University Medical Center Göttingen, 37075 Göttingen, Germany.; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Johnsen+SA%22">Johnsen SA</searchLink>; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Najafova+Z%22">Najafova Z</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.
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