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Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.

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Title: Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
Authors: Chen X; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Wolfe DA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Bindu DS; Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA., Zhang M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Taskin N; Allen Institute for Brain Science, Seattle, WA, USA., Goertsen D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Shay TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Sullivan EE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Huang SF; Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland., Ravindra Kumar S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Arokiaraj CM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Plattner VM; Sainsbury Wellcome Centre, University College London, London, UK., Campos LJ; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA., Mich JK; Allen Institute for Brain Science, Seattle, WA, USA., Monet D; Allen Institute for Brain Science, Seattle, WA, USA., Ngo V; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA., Ding X; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Omstead V; Allen Institute for Brain Science, Seattle, WA, USA., Weed N; Allen Institute for Brain Science, Seattle, WA, USA., Bishaw Y; Allen Institute for Brain Science, Seattle, WA, USA., Gore BB; Allen Institute for Brain Science, Seattle, WA, USA., Lein ES; Allen Institute for Brain Science, Seattle, WA, USA., Akrami A; Sainsbury Wellcome Centre, University College London, London, UK., Miller C; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA., Levi BP; Allen Institute for Brain Science, Seattle, WA, USA., Keller A; Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Zürich, Switzerland., Ting JT; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Fox AS; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA., Eroglu C; Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA., Gradinaru V; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. viviana@caltech.edu.
Source: Nature communications [Nat Commun] 2023 Jun 08; Vol. 14 (1), pp. 3345. Date of Electronic Publication: 2023 Jun 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.
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  Data: <searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Wolfe+DA%22">Wolfe DA</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Bindu+DS%22">Bindu DS</searchLink>; Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Taskin+N%22">Taskin N</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Goertsen+D%22">Goertsen D</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Shay+TF%22">Shay TF</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+EE%22">Sullivan EE</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Huang+SF%22">Huang SF</searchLink>; Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ravindra+Kumar+S%22">Ravindra Kumar S</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Arokiaraj+CM%22">Arokiaraj CM</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Plattner+VM%22">Plattner VM</searchLink>; Sainsbury Wellcome Centre, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Campos+LJ%22">Campos LJ</searchLink>; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Mich+JK%22">Mich JK</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Monet+D%22">Monet D</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ngo+V%22">Ngo V</searchLink>; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA.<br /><searchLink fieldCode="AU" term="%22Ding+X%22">Ding X</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.<br /><searchLink fieldCode="AU" term="%22Omstead+V%22">Omstead V</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Weed+N%22">Weed N</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bishaw+Y%22">Bishaw Y</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gore+BB%22">Gore BB</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lein+ES%22">Lein ES</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Akrami+A%22">Akrami A</searchLink>; Sainsbury Wellcome Centre, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Miller+C%22">Miller C</searchLink>; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA.<br /><searchLink fieldCode="AU" term="%22Levi+BP%22">Levi BP</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Keller+A%22">Keller A</searchLink>; Department of Neurosurgery, Clinical Neuroscience Center, Zürich University Hospital, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zürich, University of Zürich and ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ting+JT%22">Ting JT</searchLink>; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Fox+AS%22">Fox AS</searchLink>; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA.<br /><searchLink fieldCode="AU" term="%22Eroglu+C%22">Eroglu C</searchLink>; Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Gradinaru+V%22">Gradinaru V</searchLink>; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA. viviana@caltech.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2023 Jun 08; Vol. 14 (1), pp. 3345. <i>Date of Electronic Publication: </i>2023 Jun 08.
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