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Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV - Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial.

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Title: Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV - Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial.
Authors: Compagnucci A; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France., Chan MK; MRC Clinical Trials Unit at UCL, London, UK., Saïdi Y; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France., Cressey TR; AMS-CMU & IRD Research Collaboration, Faculty of Associated Medical Sciences (AMS), Chiang Mai University, Thailand., Bamford A; MRC Clinical Trials Unit at UCL, London, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; UCL Great Ormond Street Institute of Child Health, London, UK., Riault Y; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France., Coelho A; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France., Nolan A; MRC Clinical Trials Unit at UCL, London, UK., Chalermpantmetagul S; AMS-CMU & IRD Research Collaboration, Faculty of Associated Medical Sciences (AMS), Chiang Mai University, Thailand., Morkunaite G; Penta Foundation, Padova, Italy., Amuge P; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Musiime V; Joint Clinical Research Centre, Lubowa, Kampala, Uganda.; Makerere University, Department of Paediatrics and Child Health, Kampala, Uganda., Violari A; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Cotton M; FAMCRU, Department of Paediatrics & Child Health, Family Center for Research with Ubuntu, Stellenbosch University, South Africa., Kekitiinwa AR; Baylor College of Medicine Children's Foundation, Kampala, Uganda., Kaudha E; Joint Clinical Research Centre, Lubowa, Kampala, Uganda., Groenewald M; FAMCRU, Department of Paediatrics & Child Health, Family Center for Research with Ubuntu, Stellenbosch University, South Africa., Liberty AA; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa., Kanjanavanit S; Nakornping Hospital, Chiang Mai, Thailand., Volokha A; Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine., Bologna R; Hospital Garrahan, Buenos Aires, Argentina., Pavia Ruz N; Clínica para niños con VIH, UNAM/HGM; Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico., Prieto Tato L; Hospital Universitario 12 de Octubre, Madrid, Spain., Paioni P; Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Zurich, Switzerland., Marques L; Centro Materno-Infantil do Norte, CHU Porto, Porto, Portugal., Reliquet V; Infectious Diseases Department, CHU Hôtel Dieu and INSERM UIC 1413, Nantes University, Nantes, France., Niehues T; Centre for Child Health and Adolescence, Helios Klinikum Krefeld, Academic Hospital, RWTH Aachen, Krefeld, Germany., Welch SB; Department of Paediatrics, Heartlands Hospital, University Hospitals Birmingham, Birmingham, UK., Ford D; MRC Clinical Trials Unit at UCL, London, UK., Giaquinto C; Department of Women's and Children's Health, University of Padova, Padova, Italy., Gibb DM; MRC Clinical Trials Unit at UCL, London, UK., Babiker A; MRC Clinical Trials Unit at UCL, London, UK., Ramos Amador JT; Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC); Fundación para la Investigación Biomédica HCSC; Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
Corporate Authors: SMILE-PENTA17-ANRS 152 Trial Group
Source: EClinicalMedicine [EClinicalMedicine] 2023 Jun 02; Vol. 60, pp. 102025. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).
Publication Type: Journal Article
Journal Info: Publisher: The Lancet Country of Publication: England NLM ID: 101733727 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5370 (Electronic) Linking ISSN: 25895370 NLM ISO Abbreviation: EClinicalMedicine Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV - Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Compagnucci+A%22">Compagnucci A</searchLink>; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Chan+MK%22">Chan MK</searchLink>; MRC Clinical Trials Unit at UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Saïdi+Y%22">Saïdi Y</searchLink>; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Cressey+TR%22">Cressey TR</searchLink>; AMS-CMU & IRD Research Collaboration, Faculty of Associated Medical Sciences (AMS), Chiang Mai University, Thailand.<br /><searchLink fieldCode="AU" term="%22Bamford+A%22">Bamford A</searchLink>; MRC Clinical Trials Unit at UCL, London, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; UCL Great Ormond Street Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Riault+Y%22">Riault Y</searchLink>; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Coelho+A%22">Coelho A</searchLink>; INSERM SC10-US19, Essais Thérapeutiques et Maladies Infectieuses, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Nolan+A%22">Nolan A</searchLink>; MRC Clinical Trials Unit at UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Chalermpantmetagul+S%22">Chalermpantmetagul S</searchLink>; AMS-CMU & IRD Research Collaboration, Faculty of Associated Medical Sciences (AMS), Chiang Mai University, Thailand.<br /><searchLink fieldCode="AU" term="%22Morkunaite+G%22">Morkunaite G</searchLink>; Penta Foundation, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Amuge+P%22">Amuge P</searchLink>; Baylor College of Medicine Children's Foundation, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Musiime+V%22">Musiime V</searchLink>; Joint Clinical Research Centre, Lubowa, Kampala, Uganda.; Makerere University, Department of Paediatrics and Child Health, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Violari+A%22">Violari A</searchLink>; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Cotton+M%22">Cotton M</searchLink>; FAMCRU, Department of Paediatrics & Child Health, Family Center for Research with Ubuntu, Stellenbosch University, South Africa.<br /><searchLink fieldCode="AU" term="%22Kekitiinwa+AR%22">Kekitiinwa AR</searchLink>; Baylor College of Medicine Children's Foundation, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Kaudha+E%22">Kaudha E</searchLink>; Joint Clinical Research Centre, Lubowa, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Groenewald+M%22">Groenewald M</searchLink>; FAMCRU, Department of Paediatrics & Child Health, Family Center for Research with Ubuntu, Stellenbosch University, South Africa.<br /><searchLink fieldCode="AU" term="%22Liberty+AA%22">Liberty AA</searchLink>; Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Kanjanavanit+S%22">Kanjanavanit S</searchLink>; Nakornping Hospital, Chiang Mai, Thailand.<br /><searchLink fieldCode="AU" term="%22Volokha+A%22">Volokha A</searchLink>; Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.<br /><searchLink fieldCode="AU" term="%22Bologna+R%22">Bologna R</searchLink>; Hospital Garrahan, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Pavia+Ruz+N%22">Pavia Ruz N</searchLink>; Clínica para niños con VIH, UNAM/HGM; Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.<br /><searchLink fieldCode="AU" term="%22Prieto+Tato+L%22">Prieto Tato L</searchLink>; Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Paioni+P%22">Paioni P</searchLink>; Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Marques+L%22">Marques L</searchLink>; Centro Materno-Infantil do Norte, CHU Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Reliquet+V%22">Reliquet V</searchLink>; Infectious Diseases Department, CHU Hôtel Dieu and INSERM UIC 1413, Nantes University, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Niehues+T%22">Niehues T</searchLink>; Centre for Child Health and Adolescence, Helios Klinikum Krefeld, Academic Hospital, RWTH Aachen, Krefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Welch+SB%22">Welch SB</searchLink>; Department of Paediatrics, Heartlands Hospital, University Hospitals Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Ford+D%22">Ford D</searchLink>; MRC Clinical Trials Unit at UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Giaquinto+C%22">Giaquinto C</searchLink>; Department of Women's and Children's Health, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Gibb+DM%22">Gibb DM</searchLink>; MRC Clinical Trials Unit at UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Babiker+A%22">Babiker A</searchLink>; MRC Clinical Trials Unit at UCL, London, UK.<br /><searchLink fieldCode="AU" term="%22Ramos+Amador+JT%22">Ramos Amador JT</searchLink>; Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC); Fundación para la Investigación Biomédica HCSC; Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101733727%22">EClinicalMedicine</searchLink> [EClinicalMedicine] 2023 Jun 02; Vol. 60, pp. 102025. <i>Date of Electronic Publication: </i>2023 Jun 02 (<i>Print Publication: </i>2023).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22The+Lancet%22">The Lancet </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101733727 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-5370 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225895370%22">25895370 </searchLink><i>NLM ISO Abbreviation: </i>EClinicalMedicine <i>Subsets: </i>PubMed not MEDLINE
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