The new quinazoline derivative (N2-methyl-N4-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats.

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Title: The new quinazoline derivative (N2-methyl-N4-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats.
Authors: Chatturong U; Department of Physiology, Faculty of Medical Science and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand; Université de Franche-Comté, PEPITE, Besançon, 25030, France., Chootip K; Department of Physiology, Faculty of Medical Science and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand. Electronic address: krongkarnc@nu.ac.th., Martin H; Université de Franche-Comté, PEPITE, Besançon, 25030, France., Tournier-Nappey M; Université de Franche-Comté, PEPITE, Besançon, 25030, France., Ingkaninan K; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand., Temkitthawon P; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand., Sermsenaphorn S; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand., Somarin T; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand., Konsue A; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand., Gleeson MP; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand., Totoson P; Université de Franche-Comté, PEPITE, Besançon, 25030, France., Demougeot C; Université de Franche-Comté, PEPITE, Besançon, 25030, France.
Source: European journal of pharmacology [Eur J Pharmacol] 2023 Aug 15; Vol. 953, pp. 175829. Date of Electronic Publication: 2023 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
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  Data: The new quinazoline derivative (N<superscript>2</superscript>-methyl-N<superscript>4</superscript>-[(thiophen-2-yl)methyl]quinazoline-2,4-diamine) vasodilates isolated mesenteric arteries through endothelium-independent mechanisms and has acute hypotensive effects in Wistar rats.
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  Data: <searchLink fieldCode="AU" term="%22Chatturong+U%22">Chatturong U</searchLink>; Department of Physiology, Faculty of Medical Science and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand; Université de Franche-Comté, PEPITE, Besançon, 25030, France.<br /><searchLink fieldCode="AU" term="%22Chootip+K%22">Chootip K</searchLink>; Department of Physiology, Faculty of Medical Science and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand. Electronic address: krongkarnc@nu.ac.th.<br /><searchLink fieldCode="AU" term="%22Martin+H%22">Martin H</searchLink>; Université de Franche-Comté, PEPITE, Besançon, 25030, France.<br /><searchLink fieldCode="AU" term="%22Tournier-Nappey+M%22">Tournier-Nappey M</searchLink>; Université de Franche-Comté, PEPITE, Besançon, 25030, France.<br /><searchLink fieldCode="AU" term="%22Ingkaninan+K%22">Ingkaninan K</searchLink>; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Temkitthawon+P%22">Temkitthawon P</searchLink>; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand.<br /><searchLink fieldCode="AU" term="%22Sermsenaphorn+S%22">Sermsenaphorn S</searchLink>; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Somarin+T%22">Somarin T</searchLink>; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Konsue+A%22">Konsue A</searchLink>; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Gleeson+MP%22">Gleeson MP</searchLink>; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok, 10520, Thailand.<br /><searchLink fieldCode="AU" term="%22Totoson+P%22">Totoson P</searchLink>; Université de Franche-Comté, PEPITE, Besançon, 25030, France.<br /><searchLink fieldCode="AU" term="%22Demougeot+C%22">Demougeot C</searchLink>; Université de Franche-Comté, PEPITE, Besançon, 25030, France.
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  Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2023 Aug 15; Vol. 953, pp. 175829. <i>Date of Electronic Publication: </i>2023 Jun 10.
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