Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.

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Title: Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.
Authors: Cheung CCL; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Seah YHJ; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Fang J; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Orpilla NHC; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Temasek Polytechnic, Singapore, Singapore., Lau MC; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim CJ; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim X; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lee JNLW; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim JCT; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Lim S; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore., Cheng Q; Duke-NUS Medical School, Singapore, Singapore.; Center of Statistical Research, School of Statistics, Southwestern University of Finance and Economics, Chengdu, Sichuan, China., Toh HC; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Choo SP; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Lee SY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Lee JJX; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Liu J; Duke-NUS Medical School, Singapore, Singapore., Lim TKH; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Tai D; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Yeong J; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.; Singapore Immunology Network (SIgN), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.
Source: Frontiers in immunology [Front Immunol] 2023 Jun 05; Vol. 14, pp. 1150985. Date of Electronic Publication: 2023 Jun 05 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Cheung+CCL%22">Cheung CCL</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Seah+YHJ%22">Seah YHJ</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Fang+J%22">Fang J</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Orpilla+NHC%22">Orpilla NHC</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Temasek Polytechnic, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lau+MC%22">Lau MC</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+CJ%22">Lim CJ</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+X%22">Lim X</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+JNLW%22">Lee JNLW</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+JCT%22">Lim JCT</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+S%22">Lim S</searchLink>; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheng+Q%22">Cheng Q</searchLink>; Duke-NUS Medical School, Singapore, Singapore.; Center of Statistical Research, School of Statistics, Southwestern University of Finance and Economics, Chengdu, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Toh+HC%22">Toh HC</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Choo+SP%22">Choo SP</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+SY%22">Lee SY</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+JJX%22">Lee JJX</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lim+TKH%22">Lim TKH</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tai+D%22">Tai D</searchLink>; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yeong+J%22">Yeong J</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.; Singapore Immunology Network (SIgN), Agency of Science, Technology, and Research (A*STAR), Singapore, Singapore.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2023 Jun 05; Vol. 14, pp. 1150985. <i>Date of Electronic Publication: </i>2023 Jun 05 (<i>Print Publication: </i>2023).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2023.1150985
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      – Code: eng
        Text: English
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      – TitleFull: Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.
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              Text: 2023 Jun 05
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