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FOLFOXIRI Plus Cetuximab or Bevacizumab as First-Line Treatment of BRAFV600E-Mutant Metastatic Colorectal Cancer: The Randomized Phase II FIRE-4.5 (AIO KRK0116) Study.

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Title: FOLFOXIRI Plus Cetuximab or Bevacizumab as First-Line Treatment of BRAFV600E-Mutant Metastatic Colorectal Cancer: The Randomized Phase II FIRE-4.5 (AIO KRK0116) Study.
Authors: Stintzing S; Department of Hematology, Oncology, and Cancer Immunology (CCM), Charité-Universitaetsmedizin Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Heinrich K; Department of Oncology, LMU University Hospital, Munich, Germany., Tougeron D; Department of Hepato-Gastroenterology, Poitiers University Hospital and University of Poitiers, Poitiers, France., Modest DP; Department of Hematology, Oncology, and Cancer Immunology (CCM), Charité-Universitaetsmedizin Berlin, Germany., Schwaner I; Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany., Eucker J; Department of Hematology, Oncology, and Cancer Immunology (CBF), Charité-Universitaetsmedizin Berlin, Germany., Pihusch R; MVZ Praxis Pihusch, Rosenheim, Germany., Stauch M; Hematology, Oncology/Hemostaseology Kronach, Kronach, Germany., Kaiser F; VK&K Oncology GmbH, Landshut, Germany., Kahl C; Klinikum Magdeburg gGmbH, Department of Hematology, Oncology and Palliative Care Magdeburg, Germany.; Department of Internal Medicine, Clinic III-Hematology, Oncology and Palliative Care, Rostock University Medical Center, Rostock, Germany., Karthaus M; Department of Hematology, Oncology and Palliative Care, München Klinik Harlaching and Neuperlach, Munich, Germany., Müller C; Evang. Kliniken Essen-Mitte, Essen, Germany., Burkart C; Schwarzwald-Baar Klinikum Villingen-Schwenningen, Germany., Reinacher-Schick A; Department of Hematology, Oncology and Palliative Care, St Josef-Hospital, Ruhr-University Bochum, Bochum, Germany., Kasper-Virchow S; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, Essen, Germany., Fischer von Weikersthal L; Gesundheitszentrum St Marien, Amberg, Germany., Krammer-Steiner B; Department of Hematology and Oncology; Klinikum Rostock Südstadt, Rostock, Germany., Prager GW; Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria., Taieb J; Department of Hepato-Gastroenterology, Poitiers University Hospital and University of Poitiers, Poitiers, France.; Department of Gastroenterology and GI Oncology, University Paris-Cité, (Paris Descartes), SIRC CARPEM, Hopital Européen Georges Pompidou, Paris, France., Heinemann V; Department of Oncology, LMU University Hospital, Munich, Germany.; Department of Gastroenterology and GI Oncology, University Paris-Cité, (Paris Descartes), SIRC CARPEM, Hopital Européen Georges Pompidou, Paris, France.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Sep 01; Vol. 41 (25), pp. 4143-4153. Date of Electronic Publication: 2023 Jun 23.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
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  Data: FOLFOXIRI Plus Cetuximab or Bevacizumab as First-Line Treatment of BRAF<superscript>V600E</superscript>-Mutant Metastatic Colorectal Cancer: The Randomized Phase II FIRE-4.5 (AIO KRK0116) Study.
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  Data: <searchLink fieldCode="AU" term="%22Stintzing+S%22">Stintzing S</searchLink>; Department of Hematology, Oncology, and Cancer Immunology (CCM), Charité-Universitaetsmedizin Berlin, Germany.; German Cancer Consortium (DKTK), partner site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heinrich+K%22">Heinrich K</searchLink>; Department of Oncology, LMU University Hospital, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tougeron+D%22">Tougeron D</searchLink>; Department of Hepato-Gastroenterology, Poitiers University Hospital and University of Poitiers, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Modest+DP%22">Modest DP</searchLink>; Department of Hematology, Oncology, and Cancer Immunology (CCM), Charité-Universitaetsmedizin Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schwaner+I%22">Schwaner I</searchLink>; Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Eucker+J%22">Eucker J</searchLink>; Department of Hematology, Oncology, and Cancer Immunology (CBF), Charité-Universitaetsmedizin Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Pihusch+R%22">Pihusch R</searchLink>; MVZ Praxis Pihusch, Rosenheim, Germany.<br /><searchLink fieldCode="AU" term="%22Stauch+M%22">Stauch M</searchLink>; Hematology, Oncology/Hemostaseology Kronach, Kronach, Germany.<br /><searchLink fieldCode="AU" term="%22Kaiser+F%22">Kaiser F</searchLink>; VK&K Oncology GmbH, Landshut, Germany.<br /><searchLink fieldCode="AU" term="%22Kahl+C%22">Kahl C</searchLink>; Klinikum Magdeburg gGmbH, Department of Hematology, Oncology and Palliative Care Magdeburg, Germany.; Department of Internal Medicine, Clinic III-Hematology, Oncology and Palliative Care, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Karthaus+M%22">Karthaus M</searchLink>; Department of Hematology, Oncology and Palliative Care, München Klinik Harlaching and Neuperlach, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+C%22">Müller C</searchLink>; Evang. Kliniken Essen-Mitte, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Burkart+C%22">Burkart C</searchLink>; Schwarzwald-Baar Klinikum Villingen-Schwenningen, Germany.<br /><searchLink fieldCode="AU" term="%22Reinacher-Schick+A%22">Reinacher-Schick A</searchLink>; Department of Hematology, Oncology and Palliative Care, St Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Kasper-Virchow+S%22">Kasper-Virchow S</searchLink>; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+von+Weikersthal+L%22">Fischer von Weikersthal L</searchLink>; Gesundheitszentrum St Marien, Amberg, Germany.<br /><searchLink fieldCode="AU" term="%22Krammer-Steiner+B%22">Krammer-Steiner B</searchLink>; Department of Hematology and Oncology; Klinikum Rostock Südstadt, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Prager+GW%22">Prager GW</searchLink>; Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Taieb+J%22">Taieb J</searchLink>; Department of Hepato-Gastroenterology, Poitiers University Hospital and University of Poitiers, Poitiers, France.; Department of Gastroenterology and GI Oncology, University Paris-Cité, (Paris Descartes), SIRC CARPEM, Hopital Européen Georges Pompidou, Paris, France.<br /><searchLink fieldCode="AU" term="%22Heinemann+V%22">Heinemann V</searchLink>; Department of Oncology, LMU University Hospital, Munich, Germany.; Department of Gastroenterology and GI Oncology, University Paris-Cité, (Paris Descartes), SIRC CARPEM, Hopital Européen Georges Pompidou, Paris, France.
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2023 Sep 01; Vol. 41 (25), pp. 4143-4153. <i>Date of Electronic Publication: </i>2023 Jun 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+of+Clinical+Oncology%22">American Society of Clinical Oncology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309333 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-7755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220732183X%22">0732183X </searchLink><i>NLM ISO Abbreviation: </i>J Clin Oncol <i>Subsets: </i>MEDLINE
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