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A phase Ib trial of combined PKC and MEK inhibition with sotrastaurin and binimetinib in patients with metastatic uveal melanoma.

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Title: A phase Ib trial of combined PKC and MEK inhibition with sotrastaurin and binimetinib in patients with metastatic uveal melanoma.
Authors: Bauer S; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany., Larkin J; Department of Medical Oncology and Hematology, The Royal Marsden Hospital, London, United Kingdom., Hodi FS; Melanoma Center and Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MD, United States., Stephen F; Hebrew University Hadassah Medical School, The Sharett Institute of Oncology, Jerusalem, Israel.; Jacob Schachter, Sheba Medical Center at Tel Hashomer, Tel-Aviv University Medical School, Tel Aviv, Israel., Kapiteijn EHW; Department of Medical Oncology, Leiden University Medical Centre, Leiden, Netherlands., Schwartz GK; Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, United States., Calvo E; Early Phase Clinical Drug Development in Oncology, START Madrid-CIOCC, Centro Integral Oncológico Clara Campa, Madrid, Spain., Yerramilli-Rao P; Translational Clinical Oncology, Novartis Institutes for BioMedical Research, Cambridge, MA, United States., Piperno-Neumann S; Department of Medical Oncology, Institut Curie, Paris, France., Carvajal RD; Department of Medical Oncology, Leiden University Medical Centre, Leiden, Netherlands.
Source: Frontiers in oncology [Front Oncol] 2023 Jun 09; Vol. 12, pp. 975642. Date of Electronic Publication: 2023 Jun 09 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase Ib trial of combined PKC and MEK inhibition with sotrastaurin and binimetinib in patients with metastatic uveal melanoma.
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  Data: <searchLink fieldCode="AU" term="%22Bauer+S%22">Bauer S</searchLink>; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Larkin+J%22">Larkin J</searchLink>; Department of Medical Oncology and Hematology, The Royal Marsden Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hodi+FS%22">Hodi FS</searchLink>; Melanoma Center and Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MD, United States.<br /><searchLink fieldCode="AU" term="%22Stephen+F%22">Stephen F</searchLink>; Hebrew University Hadassah Medical School, The Sharett Institute of Oncology, Jerusalem, Israel.; Jacob Schachter, Sheba Medical Center at Tel Hashomer, Tel-Aviv University Medical School, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Kapiteijn+EHW%22">Kapiteijn EHW</searchLink>; Department of Medical Oncology, Leiden University Medical Centre, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schwartz+GK%22">Schwartz GK</searchLink>; Division of Hematology and Oncology, Columbia University Irving Medical Center, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Calvo+E%22">Calvo E</searchLink>; Early Phase Clinical Drug Development in Oncology, START Madrid-CIOCC, Centro Integral Oncológico Clara Campa, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Yerramilli-Rao+P%22">Yerramilli-Rao P</searchLink>; Translational Clinical Oncology, Novartis Institutes for BioMedical Research, Cambridge, MA, United States.<br /><searchLink fieldCode="AU" term="%22Piperno-Neumann+S%22">Piperno-Neumann S</searchLink>; Department of Medical Oncology, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Carvajal+RD%22">Carvajal RD</searchLink>; Department of Medical Oncology, Leiden University Medical Centre, Leiden, Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101568867%22">Frontiers in oncology</searchLink> [Front Oncol] 2023 Jun 09; Vol. 12, pp. 975642. <i>Date of Electronic Publication: </i>2023 Jun 09 (<i>Print Publication: </i>2022).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101568867 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2234-943X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222234943X%22">2234943X </searchLink><i>NLM ISO Abbreviation: </i>Front Oncol <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2023 Jun 09
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