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Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis.

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Title: Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis.
Authors: Beraldi-Magalhaes F; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Secretaria de Estado da Saúde do Paraná, Curitiba 80010-130, Brazil.; School of Medicine, Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil., Parker SL; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia., Sanches C; Department of Pharmacy, Campus Centro-Oeste Dona Lindu, Universidade Federal de São João del-Rei, Divinopolis 35501-296, Brazil., Garcia LS; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil., Souza Carvalho BK; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil., Costa AA; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil., Fachi MM; Department of Pharmacy, Campus Jardim Botânico, Universidade Federal do Paraná, Curitiba 80210-170, Brazil., de Liz MV; Department of Chemistry & Biology, Campus Curitiba, Universidade Tecnológica Federal do Paraná, Curitiba 81280-340, Brazil., de Souza AB; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil., Safe IP; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil., Pontarolo R; Department of Pharmacy, Campus Jardim Botânico, Universidade Federal do Paraná, Curitiba 80210-170, Brazil., Wallis S; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia., Lipman J; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, 30900 Nimes, France., Roberts JA; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, 30900 Nimes, France.; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia., Cordeiro-Santos M; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.; School of Medicine, Universidade Nilton Lins, Manaus 69058-040, Brazil.
Source: Tropical medicine and infectious disease [Trop Med Infect Dis] 2023 Jun 08; Vol. 8 (6). Date of Electronic Publication: 2023 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101709042 Publication Model: Electronic Cited Medium: Internet ISSN: 2414-6366 (Electronic) Linking ISSN: 24146366 NLM ISO Abbreviation: Trop Med Infect Dis Subsets: PubMed not MEDLINE
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  Data: Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Beraldi-Magalhaes+F%22">Beraldi-Magalhaes F</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.; Secretaria de Estado da Saúde do Paraná, Curitiba 80010-130, Brazil.; School of Medicine, Faculdades Pequeno Príncipe, Curitiba 80230-020, Brazil.<br /><searchLink fieldCode="AU" term="%22Parker+SL%22">Parker SL</searchLink>; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Sanches+C%22">Sanches C</searchLink>; Department of Pharmacy, Campus Centro-Oeste Dona Lindu, Universidade Federal de São João del-Rei, Divinopolis 35501-296, Brazil.<br /><searchLink fieldCode="AU" term="%22Garcia+LS%22">Garcia LS</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+Carvalho+BK%22">Souza Carvalho BK</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+AA%22">Costa AA</searchLink>; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Fachi+MM%22">Fachi MM</searchLink>; Department of Pharmacy, Campus Jardim Botânico, Universidade Federal do Paraná, Curitiba 80210-170, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Liz+MV%22">de Liz MV</searchLink>; Department of Chemistry & Biology, Campus Curitiba, Universidade Tecnológica Federal do Paraná, Curitiba 81280-340, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+AB%22">de Souza AB</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Safe+IP%22">Safe IP</searchLink>; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Pontarolo+R%22">Pontarolo R</searchLink>; Department of Pharmacy, Campus Jardim Botânico, Universidade Federal do Paraná, Curitiba 80210-170, Brazil.<br /><searchLink fieldCode="AU" term="%22Wallis+S%22">Wallis S</searchLink>; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Lipman+J%22">Lipman J</searchLink>; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, 30900 Nimes, France.<br /><searchLink fieldCode="AU" term="%22Roberts+JA%22">Roberts JA</searchLink>; UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia.; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.; Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, 30900 Nimes, France.; Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Cordeiro-Santos+M%22">Cordeiro-Santos M</searchLink>; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.; School of Medicine, Universidade Nilton Lins, Manaus 69058-040, Brazil.
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        Text: English
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