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Recombinant von Willebrand factor and tranexamic acid for heavy menstrual bleeding in patients with mild and moderate von Willebrand disease in the USA (VWDMin): a phase 3, open-label, randomised, crossover trial.

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Title: Recombinant von Willebrand factor and tranexamic acid for heavy menstrual bleeding in patients with mild and moderate von Willebrand disease in the USA (VWDMin): a phase 3, open-label, randomised, crossover trial.
Authors: Ragni MV; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA. Electronic address: ragni@pitt.edu., Rothenberger SD; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA., Feldman R; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA., Nance D; Banner MD Anderson Cancer Center, Gilbert, AZ, USA., Leavitt AD; University of California, San Francisco, CA, USA., Malec L; Versiti Blood Research Institute, Milwaukee, WI, USA., Kulkarni R; Michigan State University, East Lansing, MI, USA., Sidonio R Jr; Emory University, Atlanta, GA, USA., Kraut E; The Ohio State University, Columbus, OH, USA., Lasky J; Cure 4 the Kids, Las Vegas, NV, USA., Pruthi R; Mayo Clinic, Rochester, MN, USA., Angelini D; Cleveland Clinic, Cleveland, OH, USA., Philipp C; Rutgers University, New Brunswick, NJ, USA., Hwang N; Center for Inherited Bleeding Disorders, Orange, CA, USA., Wheeler AP; Vanderbilt University, Nashville, TN, USA., Seaman C; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA., Machin N; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA., Xavier F; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA; Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Meyer M; Vitalant Coagulation Laboratory, Pittsburgh, PA, USA., Bellissimo D; Department of Pathology, Magee Women's Hospital Clinical Genomics Laboratory, Pittsburgh, PA, USA., Humphreys G; Department of Pathology, Magee Women's Hospital Clinical Genomics Laboratory, Pittsburgh, PA, USA., Smith KJ; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA., Merricks EP; Department of Pathology and Laboratory Medicine and the UNC Blood Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Nichols TC; Department of Pathology and Laboratory Medicine and the UNC Blood Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Ivanco D; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA., Vehec D; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA., Koerbel G; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA., Althouse AD; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA.
Source: The Lancet. Haematology [Lancet Haematol] 2023 Aug; Vol. 10 (8), pp. e612-e623. Date of Electronic Publication: 2023 Jun 26.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase III; Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Recombinant von Willebrand factor and tranexamic acid for heavy menstrual bleeding in patients with mild and moderate von Willebrand disease in the USA (VWDMin): a phase 3, open-label, randomised, crossover trial.
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  Data: <searchLink fieldCode="AU" term="%22Ragni+MV%22">Ragni MV</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA. Electronic address: ragni@pitt.edu.<br /><searchLink fieldCode="AU" term="%22Rothenberger+SD%22">Rothenberger SD</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Feldman+R%22">Feldman R</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nance+D%22">Nance D</searchLink>; Banner MD Anderson Cancer Center, Gilbert, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Leavitt+AD%22">Leavitt AD</searchLink>; University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Malec+L%22">Malec L</searchLink>; Versiti Blood Research Institute, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Kulkarni+R%22">Kulkarni R</searchLink>; Michigan State University, East Lansing, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sidonio+R+Jr%22">Sidonio R Jr</searchLink>; Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kraut+E%22">Kraut E</searchLink>; The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lasky+J%22">Lasky J</searchLink>; Cure 4 the Kids, Las Vegas, NV, USA.<br /><searchLink fieldCode="AU" term="%22Pruthi+R%22">Pruthi R</searchLink>; Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Angelini+D%22">Angelini D</searchLink>; Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Philipp+C%22">Philipp C</searchLink>; Rutgers University, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+N%22">Hwang N</searchLink>; Center for Inherited Bleeding Disorders, Orange, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+AP%22">Wheeler AP</searchLink>; Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Seaman+C%22">Seaman C</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Machin+N%22">Machin N</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Xavier+F%22">Xavier F</searchLink>; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA; Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+M%22">Meyer M</searchLink>; Vitalant Coagulation Laboratory, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bellissimo+D%22">Bellissimo D</searchLink>; Department of Pathology, Magee Women's Hospital Clinical Genomics Laboratory, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Humphreys+G%22">Humphreys G</searchLink>; Department of Pathology, Magee Women's Hospital Clinical Genomics Laboratory, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+KJ%22">Smith KJ</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Merricks+EP%22">Merricks EP</searchLink>; Department of Pathology and Laboratory Medicine and the UNC Blood Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Nichols+TC%22">Nichols TC</searchLink>; Department of Pathology and Laboratory Medicine and the UNC Blood Research Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ivanco+D%22">Ivanco D</searchLink>; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vehec+D%22">Vehec D</searchLink>; Hemophilia Center of Western Pennsylvania, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Koerbel+G%22">Koerbel G</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Althouse+AD%22">Althouse AD</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101643584%22">The Lancet. Haematology</searchLink> [Lancet Haematol] 2023 Aug; Vol. 10 (8), pp. e612-e623. <i>Date of Electronic Publication: </i>2023 Jun 26.
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  Data: Randomized Controlled Trial; Clinical Trial, Phase III; Journal Article
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101643584 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3026 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523026%22">23523026 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Haematol <i>Subsets: </i>MEDLINE
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