H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas.

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Title: H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas.
Authors: Garcia-Fabiani MB; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Present address: Leloir Institute Foundation, Buenos Aires, Argentina., Haase S; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Banerjee K; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Zhu Z; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., McClellan BL; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mujeeb AA; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Li Y; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Tronrud CE; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Varela ML; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., West MEJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Yu J; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA.; Present address: Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China., Kadiyala P; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Taher AW; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Núñez FJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Alghamri MS; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Comba A; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Mendez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Nicola Candia AJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Salazar B; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Nunez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Edwards MB; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Qin T; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Cartaxo RT; Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA., Niculcea M; Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA., Koschmann C; Department of Pediatrics, Chad Carr Pediatric Brain Tumor Center, University of Michigan Medical School, MI 48109, USA., Venneti S; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Vallcorba MP; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Nasajpour E; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA., Pericoli G; Department of Onco-Hematology, Gene and Cell Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Vinci M; Department of Onco-Hematology, Gene and Cell Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy., Kleinman CL; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Jabado N; Department of Human Genetics, McGill University, Montreal, QC, H3A 0C7, Canada., Chandler JP; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Northwestern Medicine Lou & Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Sonabend AM; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Northwestern Medicine Lou & Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., DeCuypere M; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Northwestern Medicine Lou & Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Division of Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Hambardzumyan D; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Prolo LM; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA., Mahaney KB; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA., Grant GA; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA.; Present address: Department of Neurosurgery, Duke University School of Medicine, Durham, NC 27710, USA., Petritsch CK; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California, USA., Welch JD; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Sartor MA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Lowenstein PR; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA., Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Feb 05. Date of Electronic Publication: 2025 Feb 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2023.06.13.544658