Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial.

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Title: Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial.
Authors: Hunger SP; Department of Pediatrics and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: hungers@chop.edu., Tran TH; Division of Pediatric Hematology-Oncology, Charles Bruneau Cancer Center, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada., Saha V; Children's Cancer Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Tata Translational Cancer Research Centre, Tata Medical Center, Kolkata, India., Devidas M; Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, USA., Valsecchi MG; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Gastier-Foster JM; Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA; Department of Pathology, Ohio State University College of Medicine, Columbus, OH, USA., Cazzaniga G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; Genetics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Reshmi SC; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Borowitz MJ; Department of Pathology and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moorman AV; Leukaemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Heerema NA; Department of Pathology, Ohio State University College of Medicine, Columbus, OH, USA., Carroll AJ; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Martin-Regueira P; Bristol-Myers Squibb, Princeton, NJ, USA., Loh ML; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA., Raetz EA; Department of Pediatrics and Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA., Schultz KR; Pediatric Hematology-Oncology, British Columbia Children's Hospital, Vancouver, BC, Canada., Slayton WB; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA., Cario G; Department of Pediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany., Schrappe M; Department of Pediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany., Silverman LB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA., Biondi A; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Source: The Lancet. Haematology [Lancet Haematol] 2023 Jul; Vol. 10 (7), pp. e510-e520.
Publication Type: Clinical Trial, Phase II; Multicenter Study; Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Hunger+SP%22">Hunger SP</searchLink>; Department of Pediatrics and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: hungers@chop.edu.<br /><searchLink fieldCode="AU" term="%22Tran+TH%22">Tran TH</searchLink>; Division of Pediatric Hematology-Oncology, Charles Bruneau Cancer Center, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Saha+V%22">Saha V</searchLink>; Children's Cancer Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Tata Translational Cancer Research Centre, Tata Medical Center, Kolkata, India.<br /><searchLink fieldCode="AU" term="%22Devidas+M%22">Devidas M</searchLink>; Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Valsecchi+MG%22">Valsecchi MG</searchLink>; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gastier-Foster+JM%22">Gastier-Foster JM</searchLink>; Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA; Department of Pathology, Ohio State University College of Medicine, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cazzaniga+G%22">Cazzaniga G</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; Genetics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Reshmi+SC%22">Reshmi SC</searchLink>; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Borowitz+MJ%22">Borowitz MJ</searchLink>; Department of Pathology and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Moorman+AV%22">Moorman AV</searchLink>; Leukaemia Research Cytogenetics Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Heerema+NA%22">Heerema NA</searchLink>; Department of Pathology, Ohio State University College of Medicine, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Carroll+AJ%22">Carroll AJ</searchLink>; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Martin-Regueira+P%22">Martin-Regueira P</searchLink>; Bristol-Myers Squibb, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Loh+ML%22">Loh ML</searchLink>; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Raetz+EA%22">Raetz EA</searchLink>; Department of Pediatrics and Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schultz+KR%22">Schultz KR</searchLink>; Pediatric Hematology-Oncology, British Columbia Children's Hospital, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Slayton+WB%22">Slayton WB</searchLink>; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cario+G%22">Cario G</searchLink>; Department of Pediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Schrappe+M%22">Schrappe M</searchLink>; Department of Pediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Silverman+LB%22">Silverman LB</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Pediatric Hematology-Oncology, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Biondi+A%22">Biondi A</searchLink>; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101643584%22">The Lancet. Haematology</searchLink> [Lancet Haematol] 2023 Jul; Vol. 10 (7), pp. e510-e520.
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              Text: 2023 Jul
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