Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells.
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| Title: | Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells. |
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| Authors: | Wang X; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA., Liu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. liulongchao@im.ac.cn., Yue T; Aetio Biotherapy, Dallas, TX, 75247, USA., Sun Z; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Bae J; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA., Tseng KF; Aetio Biotherapy, Dallas, TX, 75247, USA., Zhang A; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Qiao J; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. Jian.Qiao@UTSouthwestern.edu., Fu YX; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. yangxinfu@tsinghua.edu.cn.; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. yangxinfu@tsinghua.edu.cn. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2023 Jul 12; Vol. 8 (1), pp. 268. Date of Electronic Publication: 2023 Jul 12. |
| Publication Type: | Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-023-01463-y |
