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Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells.

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Title: Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells.
Authors: Wang X; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA., Liu L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. liulongchao@im.ac.cn., Yue T; Aetio Biotherapy, Dallas, TX, 75247, USA., Sun Z; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Bae J; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA., Tseng KF; Aetio Biotherapy, Dallas, TX, 75247, USA., Zhang A; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Qiao J; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. Jian.Qiao@UTSouthwestern.edu., Fu YX; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. yangxinfu@tsinghua.edu.cn.; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. yangxinfu@tsinghua.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2023 Jul 12; Vol. 8 (1), pp. 268. Date of Electronic Publication: 2023 Jul 12.
Publication Type: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8<superscript>+</superscript> T cells.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. liulongchao@im.ac.cn.<br /><searchLink fieldCode="AU" term="%22Yue+T%22">Yue T</searchLink>; Aetio Biotherapy, Dallas, TX, 75247, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.; Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Bae+J%22">Bae J</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA.<br /><searchLink fieldCode="AU" term="%22Tseng+KF%22">Tseng KF</searchLink>; Aetio Biotherapy, Dallas, TX, 75247, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Qiao+J%22">Qiao J</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. Jian.Qiao@UTSouthwestern.edu.<br /><searchLink fieldCode="AU" term="%22Fu+YX%22">Fu YX</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75235, USA. yangxinfu@tsinghua.edu.cn.; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. yangxinfu@tsinghua.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2023 Jul 12; Vol. 8 (1), pp. 268. <i>Date of Electronic Publication: </i>2023 Jul 12.
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  Data: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41392-023-01463-y
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        Text: English
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              Text: 2023 Jul 12
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              Y: 2023
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