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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.

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Title: Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.
Authors: Weeks EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA. eweeks@broadinstitute.org., Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Artificial Intelligence Laboratory, Illumina, Inc., San Diego, CA, USA., Cheng NY; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Trippe BL; Program in Computational & Systems Biology, MIT, Cambridge, MA, USA.; Computer Science & Artificial Intelligence Lab, MIT, Cambridge, MA, USA., Fine RS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Vertex Pharmaceuticals Incorporated, Boston, MA, USA., Miao J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA., Patwardhan TA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Statistics, Harvard University, Cambridge, MA, USA., Kanai M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, MGH, Boston, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Tashman KC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Li T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; MD-PhD Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ordovas-Montanes J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Program in Immunology, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Smillie CS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Computational & Systems Biology, MIT, Cambridge, MA, USA., Biton M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, MGH, Boston, MA, USA.; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, MIT, Cambridge, MA, USA.; Department of Chemistry, MIT, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MMIT, Cambridge, MA, USA., Ananthakrishnan AN; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, MGH, Boston, MA, USA.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, MGH, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA, USA.; Genentech, San Francisco, CA, USA., Gupta RM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Cardiovascular Medicine and Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Lage K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Surgery, MGH, Boston, MA, USA., Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Hirschhorn JN; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; BASE Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA., Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA. finucane@broadinstitute.org.; Analytic and Translational Genetics Unit, MGH, Boston, MA, USA. finucane@broadinstitute.org.
Source: Nature genetics [Nat Genet] 2023 Aug; Vol. 55 (8), pp. 1267-1276. Date of Electronic Publication: 2023 Jul 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Weeks+EM%22">Weeks EM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. eweeks@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Ulirsch+JC%22">Ulirsch JC</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.; Artificial Intelligence Laboratory, Illumina, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+NY%22">Cheng NY</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Trippe+BL%22">Trippe BL</searchLink>; Program in Computational & Systems Biology, MIT, Cambridge, MA, USA.; Computer Science & Artificial Intelligence Lab, MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fine+RS%22">Fine RS</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; 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Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lage+K%22">Lage K</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Surgery, MGH, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ardlie+KG%22">Ardlie KG</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hirschhorn+JN%22">Hirschhorn JN</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lander+ES%22">Lander ES</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; 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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2023 Aug; Vol. 55 (8), pp. 1267-1276. <i>Date of Electronic Publication: </i>2023 Jul 13.
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