Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease.
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| Title: | Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. |
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| Authors: | Prokopiou PC; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Engels-Domínguez N; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Schultz AP; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Sepulcre J; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Koops EA; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Papp KV; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Marshall GA; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Normandin MD; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., El Fakhri G; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Rentz D; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Sperling RA; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Johnson KA; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Jacobs HIL; From the Gordon Center for Medical Imaging (P.C.P., N.E.-D., J.S., E.A.K., M.D.N., G.E.F., K.A.J., H.I.L.J.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston; Faculty of Health (N.E.-D., H.I.L.J.), Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, The Netherlands; Department of Neurology (A.P.S., K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Massachusetts General Hospital, Harvard Medical School; The Athinoula A. Martinos Center for Biomedical Imaging (A.P.S.), Department of Radiology, Massachusetts General Hospital, Harvard Medical School; and Center for Alzheimer Research and Treatment (K.V.P., G.A.M., D.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. hjacobs@mgh.harvard.edu. |
| Source: | Neurology [Neurology] 2023 Sep 19; Vol. 101 (12), pp. e1206-e1217. Date of Electronic Publication: 2023 Jul 25. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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