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Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.

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Title: Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.
Authors: Dolan MJ; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Therrien M; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Jereb S; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kamath T; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Gazestani V; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Atkeson T; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Marsh SE; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Goeva A; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lojek NM; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Murphy S; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA., White CM; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA., Joung J; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA.; Department of Biological Engineering, MIT, Cambridge, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Department of Brain and Cognitive Science, MIT, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA., Liu B; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA., Limone F; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Leiden University Medical Center, LUMC, Leiden, the Netherlands., Eggan K; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Hacohen N; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA.; Department of Medicine, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Bernstein BE; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.; Departments of Cell Biology and Pathology, Harvard Medical School, Boston, MA, USA., Glass CK; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Leinonen V; Department of Neurosurgery, Kuopio University Hospital and Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland, Kuopio, Finland., Blurton-Jones M; Department of Neurobiology and Behavior, Sue and Bill Gross Stem Cell Research Center, UCI Institute for Memory Impairments and Neurological Disorders, Institute for Immunology, University of California, Irvine, CA, USA., Zhang F; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA.; Department of Biological Engineering, MIT, Cambridge, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Department of Brain and Cognitive Science, MIT, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA., Epstein CB; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA., Macosko EZ; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. emacosko@broadinstitute.org.; Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA. emacosko@broadinstitute.org., Stevens B; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA. Beth.Stevens@childrens.harvard.edu.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.; Harvard Medical School, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA. Beth.Stevens@childrens.harvard.edu.; Howard Hughes Medical Institute, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.
Source: Nature immunology [Nat Immunol] 2023 Aug; Vol. 24 (8), pp. 1382-1390. Date of Electronic Publication: 2023 Jul 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro.
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  Data: <searchLink fieldCode="AU" term="%22Dolan+MJ%22">Dolan MJ</searchLink>; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Therrien+M%22">Therrien M</searchLink>; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jereb+S%22">Jereb S</searchLink>; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Boston Children's Hospital, F.M. 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Beth.Stevens@childrens.harvard.edu.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.; Harvard Medical School, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.; Broad Institute of MIT and Harvard Cambridge, Cambridge, MA, USA. Beth.Stevens@childrens.harvard.edu.; Howard Hughes Medical Institute, Boston, MA, USA. Beth.Stevens@childrens.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2023 Aug; Vol. 24 (8), pp. 1382-1390. <i>Date of Electronic Publication: </i>2023 Jul 27.
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