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Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade.

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Title: Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade.
Authors: Baruch EN; Division of Cancer Medicine, Hematology and Oncology Fellowship program, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nagarajan P; Department of Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gleber-Netto FO; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rao X; Department of Bioinformatics and Computational Biology, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Xie T; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Akhter S; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Adewale A; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Shajedul I; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mattson BJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ferrarotto R; Department of Head and Neck Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wong MK; Department of Melanoma Medical Oncology, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Davies MA; Department of Melanoma Medical Oncology, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jindal S; Department of Immunology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Basu S; Department of Immunology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Harwood C; Department of Dermatology, Royal London Hospital, Barts Health NHS Trust, Centre for Cell Biology and Cutaneous Research, Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London, UK., Leigh I; Department of Dermatology, Royal London Hospital, Barts Health NHS Trust, Centre for Cell Biology and Cutaneous Research, Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London, UK., Ajami N; Department of Genomic Medicine, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Futreal A; Department of Genomic Medicine, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Castillo M; Department of Biology and Biochemistry, University of Houston Sequencing and Gene Editing Core, University of Houston, Houston, TX, USA., Gunaratne P; Department of Biology and Biochemistry, University of Houston Sequencing and Gene Editing Core, University of Houston, Houston, TX, USA., Goepfert RP; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khushalani N; Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA., Wang J; Department of Bioinformatics and Computational Biology, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Watowich S; Department of Immunology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Calin GA; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Migden MR; Department of Dermatology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vermeer P; Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, SD, USA., D'Silva N; Department of Dentistry & Pathology, the University of Michigan, Ann Arbor, MI, USA., Yaniv D; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Burks JK; Department of Leukemia, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gomez J; Department of Leukemia, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dougherty PM; Department of Pain Medicine, Division of Anesthesiology, Critical Care, and Pain Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tsai KY; Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA., Allison JP; Department of Immunology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sharma P; Department of Immunology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wargo J; Department of Genomic Medicine, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Myers JN; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gross ND; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Amit M; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX.
Source: Research square [Res Sq] 2023 Jul 18. Date of Electronic Publication: 2023 Jul 18.
Publication Type: Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Department of Dentistry & Pathology, the University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yaniv+D%22">Yaniv D</searchLink>; Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Burks+JK%22">Burks JK</searchLink>; Department of Leukemia, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gomez+J%22">Gomez J</searchLink>; Department of Leukemia, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dougherty+PM%22">Dougherty PM</searchLink>; Department of Pain Medicine, Division of Anesthesiology, Critical Care, and Pain Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tsai+KY%22">Tsai KY</searchLink>; Department of Tumor Biology, Moffitt Cancer Center, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Allison+JP%22">Allison JP</searchLink>; 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Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX.
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