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Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy.

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Title: Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy.
Authors: Pan M; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Solozobova V; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Kuznik NC; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Jung N; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Gräßle S; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Gourain V; Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France., Heneka YM; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Cramer von Clausbruch CA; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Fuhr O; Institute of Nanotechnology and Karlsruhe Nano Micro Facility (KNMFi), Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Munuganti RSN; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Maddalo D; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Blattner C; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Neeb A; Institute of Cancer Research, London, United Kingdom., Sharp A; Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom., Cato L; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Weiss C; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Jeselsohn RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Orian-Rousseau V; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany., Bräse S; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany., Cato ACB; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
Source: Cancer research communications [Cancer Res Commun] 2023 Jul 27; Vol. 3 (7), pp. 1378-1396. Date of Electronic Publication: 2023 Jul 27 (Print Publication: 2023).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: eCollection Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Pan+M%22">Pan M</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Solozobova+V%22">Solozobova V</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Kuznik+NC%22">Kuznik NC</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+N%22">Jung N</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Gräßle+S%22">Gräßle S</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Gourain+V%22">Gourain V</searchLink>; Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Heneka+YM%22">Heneka YM</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Cramer+von+Clausbruch+CA%22">Cramer von Clausbruch CA</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Fuhr+O%22">Fuhr O</searchLink>; Institute of Nanotechnology and Karlsruhe Nano Micro Facility (KNMFi), Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Munuganti+RSN%22">Munuganti RSN</searchLink>; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Maddalo+D%22">Maddalo D</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Blattner+C%22">Blattner C</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Neeb+A%22">Neeb A</searchLink>; Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sharp+A%22">Sharp A</searchLink>; Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cato+L%22">Cato L</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Weiss+C%22">Weiss C</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Jeselsohn+RM%22">Jeselsohn RM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Orian-Rousseau+V%22">Orian-Rousseau V</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Bräse+S%22">Bräse S</searchLink>; Institute of Biological and Chemical Systems - Functional Molecular Systems, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Cato+ACB%22">Cato ACB</searchLink>; Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.
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  Data: <searchLink fieldCode="JN" term="%229918281580506676%22">Cancer research communications</searchLink> [Cancer Res Commun] 2023 Jul 27; Vol. 3 (7), pp. 1378-1396. <i>Date of Electronic Publication: </i>2023 Jul 27 (<i>Print Publication: </i>2023).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918281580506676 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2767-9764 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227679764%22">27679764 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res Commun <i>Subsets: </i>MEDLINE
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