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A Phase II Trial of the CD40 Agonistic Antibody Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Confirmed Disease Progression on Anti-PD-1 Therapy.

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Title: A Phase II Trial of the CD40 Agonistic Antibody Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Confirmed Disease Progression on Anti-PD-1 Therapy.
Authors: Weiss SA; Yale University School of Medicine, New Haven, Connecticut., Sznol M; Yale University School of Medicine, New Haven, Connecticut., Shaheen M; University of Arizona Cancer Center, Tucson, Arizona., Berciano-Guerrero MÁ; Medical Oncology Intercenter Unit, Regional and Virgen de la Victoria University Hospitals, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain., Couselo EM; Vall d'Hebron University Hospital, Barcelona, Spain., Rodríguez-Abreu D; Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain., Boni V; START Madrid-CIOCC, Hospital Universitario HM Sanchinarro, Madrid, Spain., Schuchter LM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Gonzalez-Cao M; Instituto Oncológico, Quirón Dexeus University Hospital, Barcelona, Spain., Arance A; Hospital Clínic Barcelona, Barcelona, Spain., Wei W; Yale University School of Medicine, New Haven, Connecticut., Ganti AK; VA Nebraska Western Iowa Healthcare System and University of Nebraska Medical Center, Omaha, Nebraska., Hauke RJ; Nebraska Cancer Specialists, Omaha, Nebraska., Berrocal A; University General Hospital of Valencia, Valencia, Spain., Iannotti NO; Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie, Florida., Hsu FJ; Apexigen America, Inc., San Carlos, California., Kluger HM; Yale University School of Medicine, New Haven, Connecticut.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jan 05; Vol. 30 (1), pp. 74-81.
Publication Type: Clinical Trial, Phase II; Multicenter Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phase II Trial of the CD40 Agonistic Antibody Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Confirmed Disease Progression on Anti-PD-1 Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Weiss+SA%22">Weiss SA</searchLink>; Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Sznol+M%22">Sznol M</searchLink>; Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Shaheen+M%22">Shaheen M</searchLink>; University of Arizona Cancer Center, Tucson, Arizona.<br /><searchLink fieldCode="AU" term="%22Berciano-Guerrero+MÁ%22">Berciano-Guerrero MÁ</searchLink>; Medical Oncology Intercenter Unit, Regional and Virgen de la Victoria University Hospitals, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Couselo+EM%22">Couselo EM</searchLink>; Vall d'Hebron University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Abreu+D%22">Rodríguez-Abreu D</searchLink>; Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain.<br /><searchLink fieldCode="AU" term="%22Boni+V%22">Boni V</searchLink>; START Madrid-CIOCC, Hospital Universitario HM Sanchinarro, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Schuchter+LM%22">Schuchter LM</searchLink>; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Cao+M%22">Gonzalez-Cao M</searchLink>; Instituto Oncológico, Quirón Dexeus University Hospital, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arance+A%22">Arance A</searchLink>; Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wei+W%22">Wei W</searchLink>; Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Ganti+AK%22">Ganti AK</searchLink>; VA Nebraska Western Iowa Healthcare System and University of Nebraska Medical Center, Omaha, Nebraska.<br /><searchLink fieldCode="AU" term="%22Hauke+RJ%22">Hauke RJ</searchLink>; Nebraska Cancer Specialists, Omaha, Nebraska.<br /><searchLink fieldCode="AU" term="%22Berrocal+A%22">Berrocal A</searchLink>; University General Hospital of Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Iannotti+NO%22">Iannotti NO</searchLink>; Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie, Florida.<br /><searchLink fieldCode="AU" term="%22Hsu+FJ%22">Hsu FJ</searchLink>; Apexigen America, Inc., San Carlos, California.<br /><searchLink fieldCode="AU" term="%22Kluger+HM%22">Kluger HM</searchLink>; Yale University School of Medicine, New Haven, Connecticut.
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  Data: Clinical Trial, Phase II; Multicenter Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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