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Multi-PGS enhances polygenic prediction by combining 937 polygenic scores.

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Title: Multi-PGS enhances polygenic prediction by combining 937 polygenic scores.
Authors: Albiñana C; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark. albinanaclara@gmail.com.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark. albinanaclara@gmail.com., Zhu Z; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark., Schork AJ; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, 2100, Denmark.; The Translational Genomics Research Institute, Phoenix, AZ, USA., Ingason A; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, 2100, Denmark., Aschard H; Department of Computational Biology, Institut Pasteur, Université de Paris, 25-28 Rue du Dr Roux, 75015, Paris, France., Brikell I; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000, Aarhus C, Denmark.; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden., Bulik CM; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Petersen LV; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark., Agerbo E; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark., Grove J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000, Aarhus C, Denmark.; Center for Genomics and Personalized Medicine, Aarhus University, 8000, Aarhus C, Denmark.; Bioinformatics Research Centre, Aarhus University, 8000, Aarhus C, Denmark., Nordentoft M; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Copenhagen Research Centre on Mental Health (CORE), University of Copenhagen, Copenhagen, Denmark., Hougaard DM; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, 2300, Copenhagen S, Denmark., Werge T; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, 2100, Denmark.; Lundbeck Foundation Centre for GeoGenetics, GLOBE Institute, University of Copenhagen, 1350, Copenhagen K, Denmark., Børglum AD; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000, Aarhus C, Denmark.; Center for Genomics and Personalized Medicine, Aarhus University, 8000, Aarhus C, Denmark., Mortensen PB; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark., McGrath JJ; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark.; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Brisbane, QLD, 4076, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, QLD, 4072, Australia., Neale BM; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Privé F; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark., Vilhjálmsson BJ; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark. bjv.ncrr@au.dk.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark. bjv.ncrr@au.dk.; Bioinformatics Research Centre, Aarhus University, 8000, Aarhus C, Denmark. bjv.ncrr@au.dk.; Novo Nordisk Foundation Center for Genomic Mechanisms, Broad Institute of MIT and Harvard, Cambridge, MA, USA. bjv.ncrr@au.dk.
Source: Nature communications [Nat Commun] 2023 Aug 05; Vol. 14 (1), pp. 4702. Date of Electronic Publication: 2023 Aug 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multi-PGS enhances polygenic prediction by combining 937 polygenic scores.
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  Data: <searchLink fieldCode="AU" term="%22Albiñana+C%22">Albiñana C</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark. albinanaclara@gmail.com.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark. albinanaclara@gmail.com.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark.<br /><searchLink fieldCode="AU" term="%22Schork+AJ%22">Schork AJ</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, 2100, Denmark.; The Translational Genomics Research Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Ingason+A%22">Ingason A</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, 2100, Denmark.<br /><searchLink fieldCode="AU" term="%22Aschard+H%22">Aschard H</searchLink>; Department of Computational Biology, Institut Pasteur, Université de Paris, 25-28 Rue du Dr Roux, 75015, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brikell+I%22">Brikell I</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000, Aarhus C, Denmark.; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bulik+CM%22">Bulik CM</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.<br /><searchLink fieldCode="AU" term="%22Petersen+LV%22">Petersen LV</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark.<br /><searchLink fieldCode="AU" term="%22Agerbo+E%22">Agerbo E</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark.<br /><searchLink fieldCode="AU" term="%22Grove+J%22">Grove J</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000, Aarhus C, Denmark.; Center for Genomics and Personalized Medicine, Aarhus University, 8000, Aarhus C, Denmark.; Bioinformatics Research Centre, Aarhus University, 8000, Aarhus C, Denmark.<br /><searchLink fieldCode="AU" term="%22Nordentoft+M%22">Nordentoft M</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Copenhagen Research Centre on Mental Health (CORE), University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hougaard+DM%22">Hougaard DM</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, 2300, Copenhagen S, Denmark.<br /><searchLink fieldCode="AU" term="%22Werge+T%22">Werge T</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, 2100, Denmark.; Lundbeck Foundation Centre for GeoGenetics, GLOBE Institute, University of Copenhagen, 1350, Copenhagen K, Denmark.<br /><searchLink fieldCode="AU" term="%22Børglum+AD%22">Børglum AD</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, 8000, Aarhus C, Denmark.; Center for Genomics and Personalized Medicine, Aarhus University, 8000, Aarhus C, Denmark.<br /><searchLink fieldCode="AU" term="%22Mortensen+PB%22">Mortensen PB</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark.<br /><searchLink fieldCode="AU" term="%22McGrath+JJ%22">McGrath JJ</searchLink>; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark.; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Brisbane, QLD, 4076, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, QLD, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Neale+BM%22">Neale BM</searchLink>; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Privé+F%22">Privé F</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark.<br /><searchLink fieldCode="AU" term="%22Vilhjálmsson+BJ%22">Vilhjálmsson BJ</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210, Aarhus V, Denmark. bjv.ncrr@au.dk.; National Centre for Register-Based Research, Aarhus University, 8210, Aarhus V, Denmark. bjv.ncrr@au.dk.; Bioinformatics Research Centre, Aarhus University, 8000, Aarhus C, Denmark. bjv.ncrr@au.dk.; Novo Nordisk Foundation Center for Genomic Mechanisms, Broad Institute of MIT and Harvard, Cambridge, MA, USA. bjv.ncrr@au.dk.
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