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Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.

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Title: Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.
Authors: Guarnieri JW; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Dybas JM; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Fazelinia H; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Kim MS; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, South Korea., Frere J; Icahn School of Medicine at Mount Sinai, New York, NY 10023, USA., Zhang Y; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Soto Albrecht Y; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Murdock DG; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Angelin A; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Singh LN; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Weiss SL; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Best SM; COVID-19 International Research Team, Medford, MA 02155, USA .; Rocky Mountain Laboratory, National Institute of Allergy and Infectious Disease, NIH, Hamilton, MT 59840, USA., Lott MT; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Zhang S; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Cope H; University of Nottingham, Nottingham, UK., Zaksas V; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Chicago, Chicago, IL 60615, USA.; Clever Research Lab, Springfield, IL 62704, USA., Saravia-Butler A; COVID-19 International Research Team, Medford, MA 02155, USA .; Logyx, LLC, Mountain View, CA 94043, USA.; NASA Ames Research Center, Moffett Field, CA 94035, USA., Meydan C; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA., Foox J; Weill Cornell Medicine, New York, NY 10065, USA., Mozsary C; Weill Cornell Medicine, New York, NY 10065, USA., Bram Y; Weill Cornell Medicine, New York, NY 10065, USA., Kidane Y; COVID-19 International Research Team, Medford, MA 02155, USA .; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA., Priebe W; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Emmett MR; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Texas Medical Branch, Galveston, TX 77555, USA., Meller R; COVID-19 International Research Team, Medford, MA 02155, USA .; Morehouse School of Medicine, Atlanta, GA 30310, USA., Demharter S; DKAbzu ApS, Copenhagen 2150, Denmark., Stentoft-Hansen V; DKAbzu ApS, Copenhagen 2150, Denmark., Salvatore M; DKAbzu ApS, Copenhagen 2150, Denmark., Galeano D; COVID-19 International Research Team, Medford, MA 02155, USA .; Facultad de Ingeniería, Universidad Nacional de Asunción, San Lorenzo, Central, Paraguay., Enguita FJ; COVID-19 International Research Team, Medford, MA 02155, USA .; Faculdade de Medicina, Universidade de Lisboa, Instituto de Medicina Molecular João Lobo Antunes, 1649-028 Lisboa, Portugal., Grabham P; College of Physicians and Surgeons, Columbia University, New York, NY 19103, USA., Trovao NS; COVID-19 International Research Team, Medford, MA 02155, USA .; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA., Singh U; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Haltom J; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Heise MT; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Moorman NJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baxter VK; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Madden EA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Taft-Benz SA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Anderson EJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sanders WA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dickmander RJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baylin SB; COVID-19 International Research Team, Medford, MA 02155, USA .; Johns Hopkins School of Medicine, Baltimore, MD 21287, USA., Wurtele ES; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Moraes-Vieira PM; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Campinas, Campinas, SP, Brazil., Taylor D; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Mason CE; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA.; New York Genome Center, New York, NY 10013, USA., Schisler JC; COVID-19 International Research Team, Medford, MA 02155, USA .; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Schwartz RE; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA., Beheshti A; COVID-19 International Research Team, Medford, MA 02155, USA .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA., Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Division of Human Genetics, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Source: Science translational medicine [Sci Transl Med] 2023 Aug 09; Vol. 15 (708), pp. eabq1533. Date of Electronic Publication: 2023 Aug 09.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.abq1533