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Step-in dosing of bosutinib in pts with chronic phase chronic myeloid leukemia (CML) after second-generation tyrosine kinase inhibitor (TKI) therapy: results of the Bosutinib Dose Optimization (BODO) Study.

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Title: Step-in dosing of bosutinib in pts with chronic phase chronic myeloid leukemia (CML) after second-generation tyrosine kinase inhibitor (TKI) therapy: results of the Bosutinib Dose Optimization (BODO) Study.
Authors: Isfort S; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany. sisfort@ukaachen.de.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany. sisfort@ukaachen.de., Manz K; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Teichmann LL; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.; Department of Medicine III, University Hospital Bonn, Bonn, Germany., Crysandt M; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany., Burchert A; Dep. of Internal Medicine, Hematology, Oncology and Immunology, Philips Univ. Marburg, Marburg, Germany., Hochhaus A; Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany., Saussele S; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg, Germany., Kiani A; Department of Oncology and Hematology, Klinikum Bayreuth, Bayreuth, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany., Göthert JR; Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Illmer T; Hematology-Oncology Practice, Dresden, Germany., Schafhausen P; Department of Oncology, Hematology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Al-Ali HK; University Hospital Halle, Halle (Saale), Germany., Stegelmann F; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Hänel M; Department of Internal Medicine III, Küchwald Hospital Chemnitz, Chemnitz, Germany., Pfeiffer T; Department of Hematology and Oncology, Klinikum Augsburg, Augsburg, Germany., Giagounidis A; Clinic for Oncology, Hematology, and Palliative Medicine, Marien Hospital Düsseldorf, Düsseldorf, Germany., Franke GN; Medical Clinic I, University Hospital of Leipzig, Leipzig, Germany., Koschmieder S; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany., Fabarius A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg, Germany., Ernst T; Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany., Warnken-Uhlich M; Clinical Study Core Unit Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Bonn, Germany., Wolber U; Clinical Study Core Unit Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Bonn, Germany., Kohn D; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany., Pfirrmann M; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany., Wolf D; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.; Department of Medicine III, University Hospital Bonn, Bonn, Germany.; Internal Medicine V, Department for Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck (MUI), Innsbruck, Austria., Brümmendorf TH; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.
Corporate Authors: German CML study group
Source: Annals of hematology [Ann Hematol] 2023 Oct; Vol. 102 (10), pp. 2741-2752. Date of Electronic Publication: 2023 Aug 18.
Publication Type: Clinical Trial, Phase II; Multicenter Study; Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Step-in dosing of bosutinib in pts with chronic phase chronic myeloid leukemia (CML) after second-generation tyrosine kinase inhibitor (TKI) therapy: results of the Bosutinib Dose Optimization (BODO) Study.
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  Data: <searchLink fieldCode="AU" term="%22Isfort+S%22">Isfort S</searchLink>; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany. sisfort@ukaachen.de.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany. sisfort@ukaachen.de.<br /><searchLink fieldCode="AU" term="%22Manz+K%22">Manz K</searchLink>; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Teichmann+LL%22">Teichmann LL</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.; Department of Medicine III, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Crysandt+M%22">Crysandt M</searchLink>; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Burchert+A%22">Burchert A</searchLink>; Dep. of Internal Medicine, Hematology, Oncology and Immunology, Philips Univ. Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hochhaus+A%22">Hochhaus A</searchLink>; Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Saussele+S%22">Saussele S</searchLink>; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kiani+A%22">Kiani A</searchLink>; Department of Oncology and Hematology, Klinikum Bayreuth, Bayreuth, Germany.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Göthert+JR%22">Göthert JR</searchLink>; Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Illmer+T%22">Illmer T</searchLink>; Hematology-Oncology Practice, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schafhausen+P%22">Schafhausen P</searchLink>; Department of Oncology, Hematology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Ali+HK%22">Al-Ali HK</searchLink>; University Hospital Halle, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Stegelmann+F%22">Stegelmann F</searchLink>; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Hänel+M%22">Hänel M</searchLink>; Department of Internal Medicine III, Küchwald Hospital Chemnitz, Chemnitz, Germany.<br /><searchLink fieldCode="AU" term="%22Pfeiffer+T%22">Pfeiffer T</searchLink>; Department of Hematology and Oncology, Klinikum Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Giagounidis+A%22">Giagounidis A</searchLink>; Clinic for Oncology, Hematology, and Palliative Medicine, Marien Hospital Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Franke+GN%22">Franke GN</searchLink>; Medical Clinic I, University Hospital of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Koschmieder+S%22">Koschmieder S</searchLink>; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Fabarius+A%22">Fabarius A</searchLink>; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ernst+T%22">Ernst T</searchLink>; Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Warnken-Uhlich+M%22">Warnken-Uhlich M</searchLink>; Clinical Study Core Unit Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wolber+U%22">Wolber U</searchLink>; Clinical Study Core Unit Bonn, Institute of Clinical Chemistry and Clinical Pharmacology, University Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kohn+D%22">Kohn D</searchLink>; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pfirrmann+M%22">Pfirrmann M</searchLink>; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+D%22">Wolf D</searchLink>; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.; Department of Medicine III, University Hospital Bonn, Bonn, Germany.; Internal Medicine V, Department for Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck (MUI), Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Brümmendorf+TH%22">Brümmendorf TH</searchLink>; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen Bonn Cologne Düsseldorf, Germany.
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