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Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial.

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Title: Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial.
Authors: Koopman I; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Tack RW; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Wunderink HF; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Bruns AH; Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van der Schaaf IC; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Cianci D; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Gelderman KA; Sanquin Diagnostic Services, Amsterdam, The Netherlands., van de Ridder IM; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hol EM; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Rinkel GJ; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Vergouwen MD; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Source: European stroke journal [Eur Stroke J] 2023 Dec; Vol. 8 (4), pp. 1097-1106. Date of Electronic Publication: 2023 Aug 22.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: SAGE Publications Ltd Country of Publication: England NLM ID: 101688446 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2396-9881 (Electronic) Linking ISSN: 23969873 NLM ISO Abbreviation: Eur Stroke J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Koopman+I%22">Koopman I</searchLink>; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tack+RW%22">Tack RW</searchLink>; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wunderink+HF%22">Wunderink HF</searchLink>; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bruns+AH%22">Bruns AH</searchLink>; Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Schaaf+IC%22">van der Schaaf IC</searchLink>; Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Cianci+D%22">Cianci D</searchLink>; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gelderman+KA%22">Gelderman KA</searchLink>; Sanquin Diagnostic Services, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Ridder+IM%22">van de Ridder IM</searchLink>; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hol+EM%22">Hol EM</searchLink>; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rinkel+GJ%22">Rinkel GJ</searchLink>; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vergouwen+MD%22">Vergouwen MD</searchLink>; Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101688446%22">European stroke journal</searchLink> [Eur Stroke J] 2023 Dec; Vol. 8 (4), pp. 1097-1106. <i>Date of Electronic Publication: </i>2023 Aug 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications+Ltd%22">SAGE Publications Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101688446 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2396-9881 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223969873%22">23969873 </searchLink><i>NLM ISO Abbreviation: </i>Eur Stroke J <i>Subsets: </i>MEDLINE
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              Text: 2023 Dec
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