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RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts.

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Title: RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts.
Authors: Watts GF; School of Medicine, University of Western Australia, Perth, Western Australia, Australia. gerald.watts@uwa.edu.au., Schwabe C; Auckland Clinical Studies, Auckland, New Zealand., Scott R; New Zealand Clinical Research Christchurch, Christchurch, New Zealand., Gladding PA; Te Whatu Ora Waitematā, Auckland, New Zealand., Sullivan D; Royal Prince Alfred Hospital, Sydney, New South Wales, Australia., Baker J; Middlemore Hospital, Auckland, New Zealand., Clifton P; Royal Adelaide Hospital, Adelaide, South Australia, Australia., Hamilton J; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA., Given B; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA., Melquist S; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA., Zhou R; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA., Chang T; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA., San Martin J; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA., Gaudet D; Department of Medicine, Université de Montréal and ECOGENE 21 Clinical Research Center, Chicoutimi, Quebec, Canada., Goldberg IJ; NYU School of Medicine, NYU Langone Health, New York City, NY, USA., Knowles JW; Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, School of Medicine, Stanford, CA, USA., Hegele RA; University of Western Ontario, London, Ontario, Canada., Ballantyne CM; Baylor College of Medicine, Houston, TX, USA.
Source: Nature medicine [Nat Med] 2023 Sep; Vol. 29 (9), pp. 2216-2223. Date of Electronic Publication: 2023 Aug 25.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Watts+GF%22">Watts GF</searchLink>; School of Medicine, University of Western Australia, Perth, Western Australia, Australia. gerald.watts@uwa.edu.au.<br /><searchLink fieldCode="AU" term="%22Schwabe+C%22">Schwabe C</searchLink>; Auckland Clinical Studies, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Scott+R%22">Scott R</searchLink>; New Zealand Clinical Research Christchurch, Christchurch, New Zealand.<br /><searchLink fieldCode="AU" term="%22Gladding+PA%22">Gladding PA</searchLink>; Te Whatu Ora Waitematā, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Sullivan+D%22">Sullivan D</searchLink>; Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Baker+J%22">Baker J</searchLink>; Middlemore Hospital, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Clifton+P%22">Clifton P</searchLink>; Royal Adelaide Hospital, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Hamilton+J%22">Hamilton J</searchLink>; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Given+B%22">Given B</searchLink>; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Melquist+S%22">Melquist S</searchLink>; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+R%22">Zhou R</searchLink>; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+T%22">Chang T</searchLink>; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22San+Martin+J%22">San Martin J</searchLink>; Arrowhead Pharmaceuticals, Inc., Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gaudet+D%22">Gaudet D</searchLink>; Department of Medicine, Université de Montréal and ECOGENE 21 Clinical Research Center, Chicoutimi, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Goldberg+IJ%22">Goldberg IJ</searchLink>; NYU School of Medicine, NYU Langone Health, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Knowles+JW%22">Knowles JW</searchLink>; Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hegele+RA%22">Hegele RA</searchLink>; University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ballantyne+CM%22">Ballantyne CM</searchLink>; Baylor College of Medicine, Houston, TX, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2023 Sep; Vol. 29 (9), pp. 2216-2223. <i>Date of Electronic Publication: </i>2023 Aug 25.
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