Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene.
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| Title: | Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene. |
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| Authors: | Campbell JL Jr; Ramboll US Corporation, Raleigh, NC, United States., Clewell HJ 3rd; Ramboll US Corporation, Raleigh, NC, United States., Van Landingham C; Ramboll US Corporation, Monroe, LA, United States., Gentry PR; Ramboll US Corporation, Monroe, LA, United States., Andersen ME; Andersen ToxConsulting, LLC, Chapel Hill, NC, United States. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2023 Aug 17; Vol. 14, pp. 1223808. Date of Electronic Publication: 2023 Aug 17 (Print Publication: 2023). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1663-9812 |
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| DOI: | 10.3389/fphar.2023.1223808 |
