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A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.

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Title: A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.
Authors: Antal CE; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA., Oh TG; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA., Aigner S; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Luo EC; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Yee BA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Campos T; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Tiriac H; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA., Rothamel KL; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Cheng Z; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA., Jiao H; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA., Wang A; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA., Hah N; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Lenkiewicz E; Mayo Clinic in Arizona, Scottsdale, AZ, 85259, USA., Lumibao JC; Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Truitt ML; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Estepa G; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Banayo E; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Bashi S; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Esparza E; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA., Munoz RM; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Diedrich JK; Mass Spectrometry Core for Proteomics and Metabolomics, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Sodir NM; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Genentech, Department of Translational Oncology, 1 DNA Way, South San Francisco, CA, 94080, USA., Mueller JR; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Fraser CR; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA.; Scottsdale Pathology Associates, Scottsdale, AZ, 85260, USA., Borazanci E; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA.; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA., Propper D; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, USA., Von Hoff DD; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA.; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA., Liddle C; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead Hospital, Westmead, NSW, 2145, Australia., Yu RT; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Atkins AR; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Han H; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Lowy AM; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA., Barrett MT; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA., Engle DD; Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Evan GI; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Yeo GW; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Sanford Stem Cell Institute, University of California San Diego, La Jolla, CA, 92037, USA., Downes M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. downes@salk.edu., Evans RM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. evans@salk.edu.
Source: Nature communications [Nat Commun] 2023 Sep 06; Vol. 14 (1), pp. 5195. Date of Electronic Publication: 2023 Sep 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Antal+CE%22">Antal CE</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Oh+TG%22">Oh TG</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Department of Oncology Science, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.<br /><searchLink fieldCode="AU" term="%22Aigner+S%22">Aigner S</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Luo+EC%22">Luo EC</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Yee+BA%22">Yee BA</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Campos+T%22">Campos T</searchLink>; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.<br /><searchLink fieldCode="AU" term="%22Tiriac+H%22">Tiriac H</searchLink>; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Rothamel+KL%22">Rothamel KL</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+Z%22">Cheng Z</searchLink>; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+H%22">Jiao H</searchLink>; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; Center for Epigenomics, University of California San Diego, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Hah+N%22">Hah N</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Lenkiewicz+E%22">Lenkiewicz E</searchLink>; Mayo Clinic in Arizona, Scottsdale, AZ, 85259, USA.<br /><searchLink fieldCode="AU" term="%22Lumibao+JC%22">Lumibao JC</searchLink>; Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Truitt+ML%22">Truitt ML</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Estepa+G%22">Estepa G</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Banayo+E%22">Banayo E</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Bashi+S%22">Bashi S</searchLink>; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Esparza+E%22">Esparza E</searchLink>; Moores Cancer Center, University of California San Diego, La Jolla, CA, 92037, USA.; Department of Surgery, Division of Surgical Oncology, University of California San Diego, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Munoz+RM%22">Munoz RM</searchLink>; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA.<br /><searchLink fieldCode="AU" term="%22Diedrich+JK%22">Diedrich JK</searchLink>; Mass Spectrometry Core for Proteomics and Metabolomics, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Sodir+NM%22">Sodir NM</searchLink>; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Genentech, Department of Translational Oncology, 1 DNA Way, South San Francisco, CA, 94080, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+JR%22">Mueller JR</searchLink>; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Fraser+CR%22">Fraser CR</searchLink>; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA.; Scottsdale Pathology Associates, Scottsdale, AZ, 85260, USA.<br /><searchLink fieldCode="AU" term="%22Borazanci+E%22">Borazanci E</searchLink>; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA.; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA.<br /><searchLink fieldCode="AU" term="%22Propper+D%22">Propper D</searchLink>; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, USA.<br /><searchLink fieldCode="AU" term="%22Von+Hoff+DD%22">Von Hoff DD</searchLink>; Molecular Medicine Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA.; HonorHealth Research Institute, Scottsdale, AZ, 85258, USA.<br /><searchLink fieldCode="AU" term="%22Liddle+C%22">Liddle C</searchLink>; 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