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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.

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Title: Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Authors: Burger WAC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Pham V; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Vuckovic Z; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Powers AS; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.; Departments of Computer Science, Structural Biology, and Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA., Mobbs JI; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Laloudakis Y; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA., Glukhova A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Tobin AB; The Advanced Research Centre (ARC), Centre for Translational Science, School of Biomolecular Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia., Paul SM; Karuna Therapeutics, Boston, MA, 02110, USA., Felder CC; Karuna Therapeutics, Boston, MA, 02110, USA., Danev R; Graduate School of Medicine, University of Tokyo, N415, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan., Dror RO; Departments of Computer Science, Structural Biology, and Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA. ron.dror@stanford.edu., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. arthur.christopoulos@monash.edu.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. arthur.christopoulos@monash.edu.; Neuromedicines Discovery Centre, Monash University, Parkville, VIC, 3052, Australia. arthur.christopoulos@monash.edu., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. celine.valant@monash.edu., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. david.thal@monash.edu.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. david.thal@monash.edu.
Source: Nature communications [Nat Commun] 2023 Sep 06; Vol. 14 (1), pp. 5440. Date of Electronic Publication: 2023 Sep 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Xanomeline displays concomitant orthosteric and allosteric binding modes at the M<subscript>4</subscript> mAChR.
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  Data: <searchLink fieldCode="AU" term="%22Burger+WAC%22">Burger WAC</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Pham+V%22">Pham V</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Vuckovic+Z%22">Vuckovic Z</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Powers+AS%22">Powers AS</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.; Departments of Computer Science, Structural Biology, and Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Mobbs+JI%22">Mobbs JI</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Laloudakis+Y%22">Laloudakis Y</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Glukhova+A%22">Glukhova A</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Wootten+D%22">Wootten D</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Tobin+AB%22">Tobin AB</searchLink>; The Advanced Research Centre (ARC), Centre for Translational Science, School of Biomolecular Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.<br /><searchLink fieldCode="AU" term="%22Sexton+PM%22">Sexton PM</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Paul+SM%22">Paul SM</searchLink>; Karuna Therapeutics, Boston, MA, 02110, USA.<br /><searchLink fieldCode="AU" term="%22Felder+CC%22">Felder CC</searchLink>; Karuna Therapeutics, Boston, MA, 02110, USA.<br /><searchLink fieldCode="AU" term="%22Danev+R%22">Danev R</searchLink>; Graduate School of Medicine, University of Tokyo, N415, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Dror+RO%22">Dror RO</searchLink>; Departments of Computer Science, Structural Biology, and Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA. ron.dror@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Christopoulos+A%22">Christopoulos A</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. arthur.christopoulos@monash.edu.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. arthur.christopoulos@monash.edu.; Neuromedicines Discovery Centre, Monash University, Parkville, VIC, 3052, Australia. arthur.christopoulos@monash.edu.<br /><searchLink fieldCode="AU" term="%22Valant+C%22">Valant C</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. celine.valant@monash.edu.<br /><searchLink fieldCode="AU" term="%22Thal+DM%22">Thal DM</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. david.thal@monash.edu.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. david.thal@monash.edu.
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