Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver.

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Title: Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver.
Authors: Peiseler M; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Araujo David B; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Zindel J; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Visceral Surgery and Medicine, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Surewaard BGJ; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Lee WY; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Heymann F; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Nusse Y; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Castanheira FVS; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Shim R; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Guillot A; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Bruneau A; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Atif J; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Perciani C; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Ohland C; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Ganguli Mukherjee P; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada., Niehrs A; Leibniz Institute of Virology (LIV), Hamburg, Germany., Thuenauer R; Leibniz Institute of Virology (LIV), Hamburg, Germany., Altfeld M; Leibniz Institute of Virology (LIV), Hamburg, Germany., Amrein M; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada., Liu Z; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Gordon PMK; Centre for Health Genomics and Informatics, University of Calgary, Calgary, Alberta, Canada., McCoy K; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Deniset J; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., MacParland S; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Gustave Roussy Cancer Campus, INSERM U1015, Villejuif, France., Tacke F; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany., Kubes P; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Source: Science (New York, N.Y.) [Science] 2023 Sep 08; Vol. 381 (6662), pp. eabq5202. Date of Electronic Publication: 2023 Sep 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver.
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  Data: <searchLink fieldCode="AU" term="%22Peiseler+M%22">Peiseler M</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Araujo+David+B%22">Araujo David B</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Zindel+J%22">Zindel J</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Visceral Surgery and Medicine, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Surewaard+BGJ%22">Surewaard BGJ</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+WY%22">Lee WY</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Heymann+F%22">Heymann F</searchLink>; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Nusse+Y%22">Nusse Y</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Castanheira+FVS%22">Castanheira FVS</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Shim+R%22">Shim R</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Guillot+A%22">Guillot A</searchLink>; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bruneau+A%22">Bruneau A</searchLink>; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Atif+J%22">Atif J</searchLink>; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Perciani+C%22">Perciani C</searchLink>; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ohland+C%22">Ohland C</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Ganguli+Mukherjee+P%22">Ganguli Mukherjee P</searchLink>; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Niehrs+A%22">Niehrs A</searchLink>; Leibniz Institute of Virology (LIV), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Thuenauer+R%22">Thuenauer R</searchLink>; Leibniz Institute of Virology (LIV), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Altfeld+M%22">Altfeld M</searchLink>; Leibniz Institute of Virology (LIV), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Amrein+M%22">Amrein M</searchLink>; Department of Cell Biology and Anatomy, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Gordon+PMK%22">Gordon PMK</searchLink>; Centre for Health Genomics and Informatics, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22McCoy+K%22">McCoy K</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Deniset+J%22">Deniset J</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22MacParland+S%22">MacParland S</searchLink>; Ajmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ginhoux+F%22">Ginhoux F</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Gustave Roussy Cancer Campus, INSERM U1015, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Tacke+F%22">Tacke F</searchLink>; Department of Hepatology and Gastroenterology, Charité Universitätsmedizin Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kubes+P%22">Kubes P</searchLink>; Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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