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Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β.

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Title: Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β.
Authors: Hommel U; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland. uli.hommel@icloud.com., Hurth K; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland. konstanze.hurth@novartis.com., Rondeau JM; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Vulpetti A; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Ostermeier D; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Boettcher A; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Brady JP; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA., Hediger M; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Lehmann S; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Koch E; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Blechschmidt A; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Yamamoto R; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Tundo Dottorello V; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Haenni-Holzinger S; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Kaiser C; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Lehr P; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Lingel A; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Mureddu L; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK., Schleberger C; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Blank J; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Ramage P; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Freuler F; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Eder J; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland., Bornancin F; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland. frederic.bornancin@novartis.com.
Source: Nature communications [Nat Commun] 2023 Sep 07; Vol. 14 (1), pp. 5497. Date of Electronic Publication: 2023 Sep 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β.
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  Data: <searchLink fieldCode="AU" term="%22Hommel+U%22">Hommel U</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland. uli.hommel@icloud.com.<br /><searchLink fieldCode="AU" term="%22Hurth+K%22">Hurth K</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland. konstanze.hurth@novartis.com.<br /><searchLink fieldCode="AU" term="%22Rondeau+JM%22">Rondeau JM</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Vulpetti+A%22">Vulpetti A</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ostermeier+D%22">Ostermeier D</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boettcher+A%22">Boettcher A</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brady+JP%22">Brady JP</searchLink>; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA.<br /><searchLink fieldCode="AU" term="%22Hediger+M%22">Hediger M</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lehmann+S%22">Lehmann S</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Koch+E%22">Koch E</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Blechschmidt+A%22">Blechschmidt A</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Yamamoto+R%22">Yamamoto R</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tundo+Dottorello+V%22">Tundo Dottorello V</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Haenni-Holzinger+S%22">Haenni-Holzinger S</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kaiser+C%22">Kaiser C</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lehr+P%22">Lehr P</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lingel+A%22">Lingel A</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mureddu+L%22">Mureddu L</searchLink>; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK.<br /><searchLink fieldCode="AU" term="%22Schleberger+C%22">Schleberger C</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Blank+J%22">Blank J</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ramage+P%22">Ramage P</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Freuler+F%22">Freuler F</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Eder+J%22">Eder J</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bornancin+F%22">Bornancin F</searchLink>; Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002, Basel, Switzerland. frederic.bornancin@novartis.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2023 Sep 07; Vol. 14 (1), pp. 5497. <i>Date of Electronic Publication: </i>2023 Sep 07.
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