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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

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Title: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
Authors: Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Jiang L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Ulrich A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Zudina L; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., González KSG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica., Balkhiyarova Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK., Faggian A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Maina JG; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Chen S; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Todorov PV; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Sharapov S; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., David A; Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK., Marullo L; Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rujan RM; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Ahlqvist E; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Gao Η; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Εvangelou Ε; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Benyamin B; Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.; Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Isaacs A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Zhao JH; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Willems SM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson T; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Meisinger C; Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; School of Health and Wellbeing, University of Glasgow, Glasgow, UK., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Corrêa IR Jr; New England Biolabs, Ipswich, MA, USA., Farber-Eger E; Vanderbilt Institute for Clinical and Translational Research and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Schmidberger J; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hveem K; K G Jebsen Centre for Genetic Epdiemiology, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Shmeliov A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., den Hoed M; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Haenle M; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore and Department of Endocrinology, Tan Tock Seng Hospital, Singapore City, Singapore., Tan TM; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Tomas A; Section of Cell Biology and Functional Genomics, Imperial College London, London, UK., Salem V; Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter, UK., Tuomilehto J; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Unit, King Abdulaziz University, Jeddah, Saudi Arabia., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Florez JC; Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Wichmann HE; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium for Healthy Ageing, the Hague, the Netherlands., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Whitfield JB; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Montgomery G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Tzoulaki I; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, Imperial College London, London, UK.; National Institute for Health Research Imperial College London Biomedical Research Centre, Imperial College London, London, UK., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Brittain EL; Vanderbilt University Medical Center and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Froguel P; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Groop L; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Deganutti G; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Demirkan A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Reynolds CA; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.; School of Life Sciences, University of Essex, Colchester, UK., Aulchenko YS; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.kaakinen@imperial.ac.uk.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk., Jones B; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK. ben.jones@imperial.ac.uk., Prokopenko I; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France. i.prokopenko@surrey.ac.uk.
Corporate Authors: GWA-PA Consortium, Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC)
Source: Nature genetics [Nat Genet] 2023 Sep; Vol. 55 (9), pp. 1448-1461. Date of Electronic Publication: 2023 Sep 07.
Publication Type: Meta-Analysis; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
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  Data: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Lagou+V%22">Lagou V</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ulrich+A%22">Ulrich A</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22Zudina+L%22">Zudina L</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22González+KSG%22">González KSG</searchLink>; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica.<br /><searchLink fieldCode="AU" term="%22Balkhiyarova+Z%22">Balkhiyarova Z</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22Faggian+A%22">Faggian A</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Maina+JG%22">Maina JG</searchLink>; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Todorov+PV%22">Todorov PV</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sharapov+S%22">Sharapov S</searchLink>; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22David+A%22">David A</searchLink>; Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Marullo+L%22">Marullo L</searchLink>; Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Mägi+R%22">Mägi R</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Rujan+RM%22">Rujan RM</searchLink>; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.<br /><searchLink fieldCode="AU" term="%22Ahlqvist+E%22">Ahlqvist E</searchLink>; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.<br /><searchLink fieldCode="AU" term="%22Thorleifsson+G%22">Thorleifsson G</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Gao+Η%22">Gao Η</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Εvangelou+Ε%22">Εvangelou Ε</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Benyamin+B%22">Benyamin B</searchLink>; Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.; Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Scott+RA%22">Scott RA</searchLink>; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Isaacs+A%22">Isaacs A</searchLink>; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhao+JH%22">Zhao JH</searchLink>; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Willems+SM%22">Willems SM</searchLink>; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Johnson+T%22">Johnson T</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gieger+C%22">Gieger C</searchLink>; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Grallert+H%22">Grallert H</searchLink>; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Meisinger+C%22">Meisinger C</searchLink>; Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Nurasyid+M%22">Müller-Nurasyid M</searchLink>; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Strawbridge+RJ%22">Strawbridge RJ</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; School of Health and Wellbeing, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Goel+A%22">Goel A</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rybin+D%22">Rybin D</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Albrecht+E%22">Albrecht E</searchLink>; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jackson+AU%22">Jackson AU</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Stringham+HM%22">Stringham HM</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Corrêa+IR+Jr%22">Corrêa IR Jr</searchLink>; New England Biolabs, Ipswich, MA, USA.<br /><searchLink fieldCode="AU" term="%22Farber-Eger+E%22">Farber-Eger E</searchLink>; Vanderbilt Institute for Clinical and Translational Research and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Steinthorsdottir+V%22">Steinthorsdottir V</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Uitterlinden+AG%22">Uitterlinden AG</searchLink>; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Munroe+PB%22">Munroe PB</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Brown+MJ%22">Brown MJ</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schmidberger+J%22">Schmidberger J</searchLink>; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Holmen+O%22">Holmen O</searchLink>; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Thorand+B%22">Thorand B</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hveem+K%22">Hveem K</searchLink>; K G Jebsen Centre for Genetic Epdiemiology, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Wilsgaard+T%22">Wilsgaard T</searchLink>; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22Mohlke+KL%22">Mohlke KL</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shmeliov+A%22">Shmeliov A</searchLink>; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22den+Hoed+M%22">den Hoed M</searchLink>; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kratzer+W%22">Kratzer W</searchLink>; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Haenle+M%22">Haenle M</searchLink>; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Koenig+W%22">Koenig W</searchLink>; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Boehm+BO%22">Boehm BO</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore and Department of Endocrinology, Tan Tock Seng Hospital, Singapore City, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+TM%22">Tan TM</searchLink>; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tomas+A%22">Tomas A</searchLink>; Section of Cell Biology and Functional Genomics, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Salem+V%22">Salem V</searchLink>; Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK.<br /><searchLink fieldCode="AU" term="%22Barroso+I%22">Barroso I</searchLink>; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Tuomilehto+J%22">Tuomilehto J</searchLink>; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Unit, King Abdulaziz University, Jeddah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Florez+JC%22">Florez JC</searchLink>; Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hamsten+A%22">Hamsten A</searchLink>; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Watkins+H%22">Watkins H</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Njølstad+I%22">Njølstad I</searchLink>; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22Wichmann+HE%22">Wichmann HE</searchLink>; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Caulfield+MJ%22">Caulfield MJ</searchLink>; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Khaw+KT%22">Khaw KT</searchLink>; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22van+Duijn+CM%22">van Duijn CM</searchLink>; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hofman+A%22">Hofman A</searchLink>; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium for Healthy Ageing, the Hague, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wareham+NJ%22">Wareham NJ</searchLink>; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Langenberg+C%22">Langenberg C</searchLink>; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Whitfield+JB%22">Whitfield JB</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Martin+NG%22">Martin NG</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Montgomery+G%22">Montgomery G</searchLink>; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Scapoli+C%22">Scapoli C</searchLink>; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Tzoulaki+I%22">Tzoulaki I</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Elliott+P%22">Elliott P</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, Imperial College London, London, UK.; National Institute for Health Research Imperial College London Biomedical Research Centre, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Thorsteinsdottir+U%22">Thorsteinsdottir U</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland.<br /><searchLink fieldCode="AU" term="%22Brittain+EL%22">Brittain EL</searchLink>; Vanderbilt University Medical Center and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+MI%22">McCarthy MI</searchLink>; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Froguel+P%22">Froguel P</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Sexton+PM%22">Sexton PM</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wootten+D%22">Wootten D</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Groop+L%22">Groop L</searchLink>; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Dupuis+J%22">Dupuis J</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Meigs+JB%22">Meigs JB</searchLink>; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Deganutti+G%22">Deganutti G</searchLink>; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.<br /><searchLink fieldCode="AU" term="%22Demirkan+A%22">Demirkan A</searchLink>; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pers+TH%22">Pers TH</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Reynolds+CA%22">Reynolds CA</searchLink>; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.; School of Life Sciences, University of Essex, Colchester, UK.<br /><searchLink fieldCode="AU" term="%22Aulchenko+YS%22">Aulchenko YS</searchLink>; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Kaakinen+MA%22">Kaakinen MA</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.kaakinen@imperial.ac.uk.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Jones+B%22">Jones B</searchLink>; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK. ben.jones@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Prokopenko+I%22">Prokopenko I</searchLink>; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France. i.prokopenko@surrey.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2023 Sep; Vol. 55 (9), pp. 1448-1461. <i>Date of Electronic Publication: </i>2023 Sep 07.
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      – TitleFull: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
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            NameFull: McCarthy MI
      – PersonEntity:
          Name:
            NameFull: Froguel P
      – PersonEntity:
          Name:
            NameFull: Sexton PM
      – PersonEntity:
          Name:
            NameFull: Wootten D
      – PersonEntity:
          Name:
            NameFull: Groop L
      – PersonEntity:
          Name:
            NameFull: Dupuis J
      – PersonEntity:
          Name:
            NameFull: Meigs JB
      – PersonEntity:
          Name:
            NameFull: Deganutti G
      – PersonEntity:
          Name:
            NameFull: Demirkan A
      – PersonEntity:
          Name:
            NameFull: Pers TH
      – PersonEntity:
          Name:
            NameFull: Reynolds CA
      – PersonEntity:
          Name:
            NameFull: Aulchenko YS
      – PersonEntity:
          Name:
            NameFull: Kaakinen MA
      – PersonEntity:
          Name:
            NameFull: Jones B
      – PersonEntity:
          Name:
            NameFull: Prokopenko I
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: 2023 Sep
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-electronic
              Value: 1546-1718
          Numbering:
            – Type: volume
              Value: 55
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Nature genetics
              Type: main
ResultId 1