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Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets.

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Title: Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets.
Authors: Frei AL; Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, PhD Program in Biomedicine, University of Zurich, Zurich, Switzerland., McGuigan A; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Sinha RR; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Glaire MA; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Jabbar F; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Gneo L; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tomasevic T; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Harkin A; Cancer Research UK Glasgow Clinical Trials Unit, University of Glasgow, Glasgow, UK., Iveson TJ; Southampton University Hospital NHS Foundation Trust, Southampton, UK., Saunders M; The Christie NHS Foundation Trust, Manchester, UK., Oein K; Glasgow Tissue Research Facility, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK., Maka N; Glasgow Tissue Research Facility, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK., Pezella F; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK., Campo L; Department of Oncology, University of Oxford, Oxford, UK., Hay J; Glasgow Tissue Research Facility, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK., Edwards J; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Sansom OJ; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Beatson Institute, Glasgow, UK.; Cancer Research UK Scotland Centre, Edinburgh and Glasgow, UK., Kelly C; Cancer Research UK Glasgow Clinical Trials Unit, University of Glasgow, Glasgow, UK., Tomlinson I; Department of Oncology, University of Oxford, Oxford, UK., Kildal W; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway., Kerr RS; Department of Oncology, University of Oxford, Oxford, UK., Kerr DJ; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK., Danielsen HE; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Department of Informatics, University of Oslo, Oslo, Norway., Domingo E; Department of Oncology, University of Oxford, Oxford, UK.; Cancer Research UK Scotland Centre, Edinburgh and Glasgow, UK., Church DN; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Comprehensive Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Koelzer VH; Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK.
Corporate Authors: TransSCOT Consortium
Source: The journal of pathology. Clinical research [J Pathol Clin Res] 2023 Nov; Vol. 9 (6), pp. 449-463. Date of Electronic Publication: 2023 Sep 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101658534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2056-4538 (Electronic) Linking ISSN: 20564538 NLM ISO Abbreviation: J Pathol Clin Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Frei+AL%22">Frei AL</searchLink>; Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Life Science Zurich Graduate School, PhD Program in Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22McGuigan+A%22">McGuigan A</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sinha+RR%22">Sinha RR</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Glaire+MA%22">Glaire MA</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jabbar+F%22">Jabbar F</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gneo+L%22">Gneo L</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tomasevic+T%22">Tomasevic T</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Harkin+A%22">Harkin A</searchLink>; Cancer Research UK Glasgow Clinical Trials Unit, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Iveson+TJ%22">Iveson TJ</searchLink>; Southampton University Hospital NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Saunders+M%22">Saunders M</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Oein+K%22">Oein K</searchLink>; Glasgow Tissue Research Facility, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Maka+N%22">Maka N</searchLink>; Glasgow Tissue Research Facility, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Pezella+F%22">Pezella F</searchLink>; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Campo+L%22">Campo L</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hay+J%22">Hay J</searchLink>; Glasgow Tissue Research Facility, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+J%22">Edwards J</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Sansom+OJ%22">Sansom OJ</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, UK.; Cancer Research UK Beatson Institute, Glasgow, UK.; Cancer Research UK Scotland Centre, Edinburgh and Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Kelly+C%22">Kelly C</searchLink>; Cancer Research UK Glasgow Clinical Trials Unit, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Tomlinson+I%22">Tomlinson I</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kildal+W%22">Kildal W</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kerr+RS%22">Kerr RS</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kerr+DJ%22">Kerr DJ</searchLink>; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Danielsen+HE%22">Danielsen HE</searchLink>; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Department of Informatics, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Domingo+E%22">Domingo E</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.; Cancer Research UK Scotland Centre, Edinburgh and Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Church+DN%22">Church DN</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Comprehensive Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Koelzer+VH%22">Koelzer VH</searchLink>; Department of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley+Blackwell%22">Wiley Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101658534 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2056-4538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220564538%22">20564538 </searchLink><i>NLM ISO Abbreviation: </i>J Pathol Clin Res <i>Subsets: </i>MEDLINE
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