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Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2.

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Title: Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2.
Authors: Stewart-Jones GBE; Moderna, Inc., Cambridge, MA 02139, USA., Elbashir SM; Moderna, Inc., Cambridge, MA 02139, USA., Wu K; Moderna, Inc., Cambridge, MA 02139, USA., Lee D; Moderna, Inc., Cambridge, MA 02139, USA., Renzi I; Moderna, Inc., Cambridge, MA 02139, USA., Ying B; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Koch M; Moderna, Inc., Cambridge, MA 02139, USA., Sein CE; Moderna, Inc., Cambridge, MA 02139, USA., Choi A; Moderna, Inc., Cambridge, MA 02139, USA., Whitener B; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Garcia-Dominguez D; Moderna, Inc., Cambridge, MA 02139, USA., Henry C; Moderna, Inc., Cambridge, MA 02139, USA., Woods A; Moderna, Inc., Cambridge, MA 02139, USA., Ma L; Moderna, Inc., Cambridge, MA 02139, USA., Montes Berrueta D; Moderna, Inc., Cambridge, MA 02139, USA., Avena LE; Moderna, Inc., Cambridge, MA 02139, USA., Quinones J; Moderna, Inc., Cambridge, MA 02139, USA., Falcone S; Moderna, Inc., Cambridge, MA 02139, USA., Hsiao CJ; Moderna, Inc., Cambridge, MA 02139, USA., Scheaffer SM; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., Thackray LB; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA., White P; Moderna, Inc., Cambridge, MA 02139, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Edwards DK; Moderna, Inc., Cambridge, MA 02139, USA., Carfi A; Moderna, Inc., Cambridge, MA 02139, USA.
Source: Science translational medicine [Sci Transl Med] 2023 Sep 13; Vol. 15 (713), pp. eadf4100. Date of Electronic Publication: 2023 Sep 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2.
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  Data: <searchLink fieldCode="AU" term="%22Stewart-Jones+GBE%22">Stewart-Jones GBE</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Elbashir+SM%22">Elbashir SM</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Renzi+I%22">Renzi I</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Ying+B%22">Ying B</searchLink>; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Koch+M%22">Koch M</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Sein+CE%22">Sein CE</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Choi+A%22">Choi A</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Whitener+B%22">Whitener B</searchLink>; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Dominguez+D%22">Garcia-Dominguez D</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Henry+C%22">Henry C</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Woods+A%22">Woods A</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Montes+Berrueta+D%22">Montes Berrueta D</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Avena+LE%22">Avena LE</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Quinones+J%22">Quinones J</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Falcone+S%22">Falcone S</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Hsiao+CJ%22">Hsiao CJ</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Scheaffer+SM%22">Scheaffer SM</searchLink>; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Thackray+LB%22">Thackray LB</searchLink>; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22White+P%22">White P</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Diamond+MS%22">Diamond MS</searchLink>; Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+DK%22">Edwards DK</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Carfi+A%22">Carfi A</searchLink>; Moderna, Inc., Cambridge, MA 02139, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2023 Sep 13; Vol. 15 (713), pp. eadf4100. <i>Date of Electronic Publication: </i>2023 Sep 13.
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