Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila.
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| Title: | Gut barrier defects, intestinal immune hyperactivation and enhanced lipid catabolism drive lethality in NGLY1-deficient Drosophila. |
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| Authors: | Pandey A; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, USA. Ashutosh.Pandey@bcm.edu., Galeone A; Department of Biosciences, University of Milan, Milan, Italy.; Institute of Nanotechnology, National Research Council (CNR-NANOTEC), Lecce, Italy., Han SY; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, USA., Story BA; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Consonni G; Department of Biosciences, University of Milan, Milan, Italy., Mueller WF; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Steinmetz LM; Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Department of Genetics, School of Medicine, Stanford University, Stanford, USA., Vaccari T; Department of Biosciences, University of Milan, Milan, Italy., Jafar-Nejad H; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, USA. hamedj@bcm.edu.; Genetics & Genomic Graduate Program, Baylor College of Medicine, Houston, USA. hamedj@bcm.edu.; Development, Disease Models & Therapeutics Graduate Program, Baylor College of Medicine, Houston, USA. hamedj@bcm.edu. |
| Source: | Nature communications [Nat Commun] 2023 Sep 13; Vol. 14 (1), pp. 5667. Date of Electronic Publication: 2023 Sep 13. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-40910-w |
