Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance.
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| Title: | Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance. |
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| Authors: | Botta C; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy. cirino.botta@unipa.it.; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain. cirino.botta@unipa.it., Perez C; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Larrayoz M; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Puig N; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), CIBER-ONC number CB16/12/00233, Salamanca, Spain., Cedena MT; Hospital Universitario 12 de Octubre, CIBER-ONC number CB16/12/00369, Madrid, Spain., Termini R; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Goicoechea I; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Rodriguez S; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Zabaleta A; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Lopez A; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Sarvide S; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Blanco L; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Papetti DM; Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy., Nobile MS; Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Venice, Italy.; Bicocca Bioinformatics, Biostatistics and Bioimaging Centre-B4, Milan, Italy., Besozzi D; Department of Informatics, Systems and Communication, University of Milano-Bicocca, Milan, Italy.; Bicocca Bioinformatics, Biostatistics and Bioimaging Centre-B4, Milan, Italy., Gentile M; Department of Oncohematology, 'Annunziata' Hospital, Cosenza, Italy., Correale P; Medical Oncology Unit, Great Metropolitan Hospital 'Riuniti' of Reggio Calabria, Reggio Calabria, Italy., Siragusa S; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy., Oriol A; Institut Català d'Oncologia i Institut Josep Carreras, Badalona, Spain., González-Garcia ME; Servicios de Medicina Interna y Hematología, Hospital de Cabueñes, Gijón, Asturias, Spain., Sureda A; Institut Català d'Oncologia-Hospitalet, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain., de Arriba F; Hospital Morales Meseguer, IMIB-Arrixaca, Universidad de Murcia, Murcia, Spain., Rios Tamayo R; Hospital Universitario Puerta de Hierro, Majadahonda, Spain., Moraleda JM; Hospital Morales Meseguer, IMIB-Arrixaca, Universidad de Murcia, Murcia, Spain., Gironella M; Hospital Vall d'Hebron, Barcelona, Spain., Hernandez MT; Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain., Bargay J; Hospital Son Llatzer, Palma de Mallorca, Spain., Palomera L; Hospital Clínico Lozano Blesa, Zaragoza, Spain., Pérez-Montaña A; Hospital Son Espases, Palma de Mallorca, Spain., Goldschmidt H; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany., Avet-Loiseau H; Unite de Genomique du Myelome, IUC-T Oncopole, Toulouse, France., Roccaro A; Department of Hematology, ASST Spedali Civili di Brescia, Brescia, BS, Italy., Orfao A; Cancer Research Center (IBMCC-CSIC/USAL-IBSAL), CIBER-ONC number CB16/12/00400, Salamanca, Spain.; Cytometry Service (NUCLEUS) and Department of Medicine, University of Salamanca, Salamanca, Spain., Martinez-Lopez J; Hospital Universitario 12 de Octubre, CIBER-ONC number CB16/12/00369, Madrid, Spain., Rosiñol L; Hospital Clínic IDIBAPS, Barcelona, Spain., Lahuerta JJ; Hospital Universitario 12 de Octubre, CIBER-ONC number CB16/12/00369, Madrid, Spain., Blade J; Hospital Clínic IDIBAPS, Barcelona, Spain., Mateos MV; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca (IBSAL), Centro de Investigación del Cancer (IBMCC-USAL, CSIC), CIBER-ONC number CB16/12/00233, Salamanca, Spain., San-Miguel JF; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Martinez Climent JA; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain., Paiva B; Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), CCUN, Instituto de Investigacion Sanitaria de Navarra (IDISNA), CIBER-ONC numbers CB16/12/00369, CB16/12/00489, Pamplona, Spain. bpaiva@unav.es. |
| Corporate Authors: | Programa Para el Estudio de la Terapéutica en Hemopatías Malignas/Grupo Español de Mieloma (PETHEMA/GEM) cooperative group, iMMunocell study group |
| Source: | Nature communications [Nat Commun] 2023 Sep 20; Vol. 14 (1), pp. 5825. Date of Electronic Publication: 2023 Sep 20. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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