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Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility.

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Title: Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility.
Authors: Schmidheini L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Mathis N; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Marquart KF; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland., Rothgangl T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Kissling L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Böck D; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Chanez C; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Wang JP; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Jinek M; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Schwank G; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. schwank@pharma.uzh.ch.
Source: Nature chemical biology [Nat Chem Biol] 2024 Mar; Vol. 20 (3), pp. 333-343. Date of Electronic Publication: 2023 Sep 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%22101231976%22">Nature chemical biology</searchLink> [Nat Chem Biol] 2024 Mar; Vol. 20 (3), pp. 333-343. <i>Date of Electronic Publication: </i>2023 Sep 21.
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