Immune Monitoring-Guided Versus Fixed Duration of Antiviral Prophylaxis Against Cytomegalovirus in Solid-Organ Transplant Recipients: A Multicenter, Randomized Clinical Trial.

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Title: Immune Monitoring-Guided Versus Fixed Duration of Antiviral Prophylaxis Against Cytomegalovirus in Solid-Organ Transplant Recipients: A Multicenter, Randomized Clinical Trial.
Authors: Manuel O; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Laager M; Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland., Hirzel C; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Neofytos D; Transplant Infectious Diseases Unit, University Hospitals Geneva and Faculty of Medicine, Geneva, Switzerland., Walti LN; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Hoenger G; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, Basel, Switzerland., Binet I; Nephrology and Transplantation Medicine, Kantonsspital St.Gallen, St. Gallen, Switzerland., Schnyder A; Nephrology and Transplantation Medicine, Kantonsspital St.Gallen, St. Gallen, Switzerland., Stampf S; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland., Koller M; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland., Mombelli M; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Kim MJ; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.; Department of Nephrology, Kantonsspital Aarau, Aarau, Switzerland., Hoffmann M; Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital St.Gallen, St. Gallen, Switzerland.; Department of Internal Medicine, Infectious Diseases and Hospital Epidemiology, Kantonsspital Olten, Olten, Switzerland., Koenig K; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.; Department of Nephrology, Kantonsspital Liestal, Liestal, Switzerland., Hess C; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, Basel, Switzerland.; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, United Kingdom., Burgener AV; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, Basel, Switzerland.; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland., Cippà PE; Clinic of Nephrology, University Hospital Zurich, Zurich, Switzerland.; Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland., Hübel K; Clinic of Nephrology, University Hospital Zurich, Zurich, Switzerland., Mueller TF; Clinic of Nephrology, University Hospital Zurich, Zurich, Switzerland., Sidler D; Division of Nephrology and Hypertension, University Hospital Bern, Bern, Switzerland., Dahdal S; Division of Nephrology and Hypertension, University Hospital Bern, Bern, Switzerland., Suter-Riniker F; Institute for Infectious Diseases, University of Bern, Bern, Switzerland., Villard J; Department of Immunology and Allergy and Department of Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland., Zbinden A; Institute of Medical Virology, University of Zurich, Zurich, Switzerland., Pantaleo G; Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Semmo N; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Hadaya K; Department of Nephrology and Hypertension, Geneva University Hospitals, Geneva, Switzerland.; Clinique des Grangettes, Hirslanden, Geneva, Switzerland., Enríquez N; Transplant Infectious Diseases Unit, University Hospitals Geneva and Faculty of Medicine, Geneva, Switzerland., Meylan PR; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Froissart M; Clinical Trial Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Golshayan D; Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Fehr T; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.; Department of Medicine, Cantonal Hospital of Chur, Chur, Switzerland., Huynh-Do U; Division of Nephrology and Hypertension, University Hospital Bern, Bern, Switzerland., Pascual M; Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., van Delden C; Transplant Infectious Diseases Unit, University Hospitals Geneva and Faculty of Medicine, Geneva, Switzerland., Hirsch HH; Infectious Diseases & Hospital Epidemiology, University Hospital of Basel, Basel, Switzerland.; Transplantation & Clinical Virology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland., Jüni P; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom., Mueller NJ; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Corporate Authors: Swiss Transplant Cohort Study (STCS)
Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Feb 17; Vol. 78 (2), pp. 312-323.
Publication Type: Randomized Controlled Trial; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immune Monitoring-Guided Versus Fixed Duration of Antiviral Prophylaxis Against Cytomegalovirus in Solid-Organ Transplant Recipients: A Multicenter, Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Manuel+O%22">Manuel O</searchLink>; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Laager+M%22">Laager M</searchLink>; Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hirzel+C%22">Hirzel C</searchLink>; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Neofytos+D%22">Neofytos D</searchLink>; Transplant Infectious Diseases Unit, University Hospitals Geneva and Faculty of Medicine, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Walti+LN%22">Walti LN</searchLink>; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hoenger+G%22">Hoenger G</searchLink>; Department of Biomedicine, Immunobiology, University of Basel and University Hospital of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Binet+I%22">Binet I</searchLink>; Nephrology and Transplantation Medicine, Kantonsspital St.Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schnyder+A%22">Schnyder A</searchLink>; Nephrology and Transplantation Medicine, Kantonsspital St.Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stampf+S%22">Stampf S</searchLink>; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Koller+M%22">Koller M</searchLink>; Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mombelli+M%22">Mombelli M</searchLink>; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; 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Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hadaya+K%22">Hadaya K</searchLink>; Department of Nephrology and Hypertension, Geneva University Hospitals, Geneva, Switzerland.; Clinique des Grangettes, Hirslanden, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Enríquez+N%22">Enríquez N</searchLink>; Transplant Infectious Diseases Unit, University Hospitals Geneva and Faculty of Medicine, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meylan+PR%22">Meylan PR</searchLink>; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Froissart+M%22">Froissart M</searchLink>; Clinical Trial Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Golshayan+D%22">Golshayan D</searchLink>; Transplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fehr+T%22">Fehr T</searchLink>; 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Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mueller+NJ%22">Mueller NJ</searchLink>; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
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