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Utility of Coproporphyrin-I Determination in First-in-Human Study for Early Evaluation of OATP1B Inhibitory Potential Based on Investigation of Ensitrelvir, an Oral SARS-CoV-2 3C-Like Protease Inhibitor.

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Title: Utility of Coproporphyrin-I Determination in First-in-Human Study for Early Evaluation of OATP1B Inhibitory Potential Based on Investigation of Ensitrelvir, an Oral SARS-CoV-2 3C-Like Protease Inhibitor.
Authors: Watari R; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan. Electronic address: ryosuke.watari@shionogi.co.jp., Sawada H; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan., Hashimoto H; Department of ADMET and Analytical Chemistry II, Shionogi TechnoAdvance Research & Co., Ltd, Japan., Kasai Y; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan., Oka R; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan., Shimizu R; Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd, Japan., Matsuzaki T; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan.
Source: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Mar; Vol. 113 (3), pp. 798-805. Date of Electronic Publication: 2023 Sep 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Utility of Coproporphyrin-I Determination in First-in-Human Study for Early Evaluation of OATP1B Inhibitory Potential Based on Investigation of Ensitrelvir, an Oral SARS-CoV-2 3C-Like Protease Inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Watari+R%22">Watari R</searchLink>; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan. Electronic address: ryosuke.watari@shionogi.co.jp.<br /><searchLink fieldCode="AU" term="%22Sawada+H%22">Sawada H</searchLink>; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan.<br /><searchLink fieldCode="AU" term="%22Hashimoto+H%22">Hashimoto H</searchLink>; Department of ADMET and Analytical Chemistry II, Shionogi TechnoAdvance Research & Co., Ltd, Japan.<br /><searchLink fieldCode="AU" term="%22Kasai+Y%22">Kasai Y</searchLink>; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan.<br /><searchLink fieldCode="AU" term="%22Oka+R%22">Oka R</searchLink>; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+R%22">Shimizu R</searchLink>; Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuzaki+T%22">Matsuzaki T</searchLink>; Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd, Japan.
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  Data: <searchLink fieldCode="JN" term="%222985195R%22">Journal of pharmaceutical sciences</searchLink> [J Pharm Sci] 2024 Mar; Vol. 113 (3), pp. 798-805. <i>Date of Electronic Publication: </i>2023 Sep 23.
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        Value: 10.1016/j.xphs.2023.09.016
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      – TitleFull: Utility of Coproporphyrin-I Determination in First-in-Human Study for Early Evaluation of OATP1B Inhibitory Potential Based on Investigation of Ensitrelvir, an Oral SARS-CoV-2 3C-Like Protease Inhibitor.
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              Text: 2024 Mar
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