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mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice.

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Title: mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice.
Authors: Li L; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.; Department of Neurosurgery, Perelman School of Medicine, Hospital of the University of Pennsylvania (L.L., Y.S.S., J.-K.B.), University of Pennsylvania, Philadelphia., Ren AA; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia., Gao S; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia., Su YS; Department of Neurosurgery, Perelman School of Medicine, Hospital of the University of Pennsylvania (L.L., Y.S.S., J.-K.B.), University of Pennsylvania, Philadelphia., Yang J; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia., Bockman J; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia., Mericko-Ishizuka P; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia., Griffin J; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia., Shenkar R; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.)., Alcazar R; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.)., Moore T; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.)., Lightle R; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.)., DeBiasse D; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.)., Awad IA; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.)., Marchuk DA; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC (D.A.M.)., Kahn ML; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia., Burkhardt JK; Department of Neurosurgery, Perelman School of Medicine, Hospital of the University of Pennsylvania (L.L., Y.S.S., J.-K.B.), University of Pennsylvania, Philadelphia.
Source: Stroke [Stroke] 2023 Nov; Vol. 54 (11), pp. 2906-2917. Date of Electronic Publication: 2023 Sep 25.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE
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  Data: mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice.
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  Data: <searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.; Department of Neurosurgery, Perelman School of Medicine, Hospital of the University of Pennsylvania (L.L., Y.S.S., J.-K.B.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Ren+AA%22">Ren AA</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Gao+S%22">Gao S</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Su+YS%22">Su YS</searchLink>; Department of Neurosurgery, Perelman School of Medicine, Hospital of the University of Pennsylvania (L.L., Y.S.S., J.-K.B.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Bockman+J%22">Bockman J</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Mericko-Ishizuka+P%22">Mericko-Ishizuka P</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Griffin+J%22">Griffin J</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Shenkar+R%22">Shenkar R</searchLink>; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.).<br /><searchLink fieldCode="AU" term="%22Alcazar+R%22">Alcazar R</searchLink>; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.).<br /><searchLink fieldCode="AU" term="%22Moore+T%22">Moore T</searchLink>; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.).<br /><searchLink fieldCode="AU" term="%22Lightle+R%22">Lightle R</searchLink>; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.).<br /><searchLink fieldCode="AU" term="%22DeBiasse+D%22">DeBiasse D</searchLink>; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.).<br /><searchLink fieldCode="AU" term="%22Awad+IA%22">Awad IA</searchLink>; Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, The University of Chicago Medicine and Biological Sciences, IL (R.S., R.A., T.M., R.L., D.D., I.A.A.).<br /><searchLink fieldCode="AU" term="%22Marchuk+DA%22">Marchuk DA</searchLink>; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC (D.A.M.).<br /><searchLink fieldCode="AU" term="%22Kahn+ML%22">Kahn ML</searchLink>; Cardiovascular Institute and Department of Medicine, Perelman School of Medicine (L.L., A.A.R., S.G., J.Y., J.B., P.M.-I., J.G., M.L.K.), University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Burkhardt+JK%22">Burkhardt JK</searchLink>; Department of Neurosurgery, Perelman School of Medicine, Hospital of the University of Pennsylvania (L.L., Y.S.S., J.-K.B.), University of Pennsylvania, Philadelphia.
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  Data: <searchLink fieldCode="JN" term="%220235266%22">Stroke</searchLink> [Stroke] 2023 Nov; Vol. 54 (11), pp. 2906-2917. <i>Date of Electronic Publication: </i>2023 Sep 25.
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        Value: 10.1161/STROKEAHA.123.044108
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