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4-Phenylbutyrate promoted wild-type γ-aminobutyric acid type A receptor trafficking, reduced endoplasmic reticulum stress, and mitigated seizures in Gabrg2+/Q390X mice associated with Dravet syndrome.

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Title: 4-Phenylbutyrate promoted wild-type γ-aminobutyric acid type A receptor trafficking, reduced endoplasmic reticulum stress, and mitigated seizures in Gabrg2+/Q390X mice associated with Dravet syndrome.
Authors: Shen W; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Flamm C; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Delahanty AJ; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Casteel E; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Biven M; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., DeLeeuw MB; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA., Poliquin S; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Nwosu G; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Randhave K; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kang JQ; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Source: Epilepsia [Epilepsia] 2024 Jan; Vol. 65 (1), pp. 204-217. Date of Electronic Publication: 2023 Nov 29.
Publication Type: Journal Article
Journal Info: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 4-Phenylbutyrate promoted wild-type γ-aminobutyric acid type A receptor trafficking, reduced endoplasmic reticulum stress, and mitigated seizures in Gabrg2<superscript>+/Q390X</superscript> mice associated with Dravet syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Shen+W%22">Shen W</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Flamm+C%22">Flamm C</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Delahanty+AJ%22">Delahanty AJ</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Casteel+E%22">Casteel E</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Biven+M%22">Biven M</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22DeLeeuw+MB%22">DeLeeuw MB</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Poliquin+S%22">Poliquin S</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Nwosu+G%22">Nwosu G</searchLink>; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Randhave+K%22">Randhave K</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Kang+JQ%22">Kang JQ</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
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  Data: <searchLink fieldCode="JN" term="%222983306R%22">Epilepsia</searchLink> [Epilepsia] 2024 Jan; Vol. 65 (1), pp. 204-217. <i>Date of Electronic Publication: </i>2023 Nov 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Blackwell+Science%22">Blackwell Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2983306R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-1167 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200139580%22">00139580 </searchLink><i>NLM ISO Abbreviation: </i>Epilepsia <i>Subsets: </i>MEDLINE
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        Value: 10.1111/epi.17779
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        Text: English
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      – TitleFull: 4-Phenylbutyrate promoted wild-type γ-aminobutyric acid type A receptor trafficking, reduced endoplasmic reticulum stress, and mitigated seizures in Gabrg2+/Q390X mice associated with Dravet syndrome.
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              Text: 2024 Jan
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