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Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors.

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Title: Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors.
Authors: Hoffman SE; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard-MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA.; PhD Program in Biological and Biomedical Sciences, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA., Dowrey TW; Section of Hematology and Medical Oncology, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA.; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA., Villacorta Martin C; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA., Bi K; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Titchen B; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; PhD Program in Biological and Biomedical Sciences, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA., Johri S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; PhD Program in Biological and Biomedical Sciences, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA., DelloStritto L; Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA., Patel M; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Mackichan C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Inga S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Chen J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Grimaldi G; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Napolitano S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Wakiro I; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Wu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Yeung J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Rotem A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Sicinska E; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Shannon E; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Clancy T; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Wang J; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Denning S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA., Brais L; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA., Besson NR; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Huang Y; Molecular Pathology Core Laboratory, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Kao KZ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Rodig S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Hornick JL; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Vigneau S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Park J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Kulke MH; Section of Hematology and Medical Oncology, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA., Chan J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Murphy GJ; Section of Hematology and Medical Oncology, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA.; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Source: Science advances [Sci Adv] 2023 Sep 29; Vol. 9 (39), pp. eadd9668. Date of Electronic Publication: 2023 Sep 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hoffman+SE%22">Hoffman SE</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Harvard-MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA.; PhD Program in Biological and Biomedical Sciences, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Dowrey+TW%22">Dowrey TW</searchLink>; Section of Hematology and Medical Oncology, Boston University School of Medicine and Boston Medical Center, Boston, MA 02118, USA.; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Villacorta+Martin+C%22">Villacorta Martin C</searchLink>; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.<br /><searchLink fieldCode="AU" term="%22Bi+K%22">Bi K</searchLink>; 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Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Grimaldi+G%22">Grimaldi G</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Napolitano+S%22">Napolitano S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Wakiro+I%22">Wakiro I</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.; 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