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A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.

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Title: A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
Authors: Garnish SE; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Martin KR; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Kauppi M; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Jackson VE; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Ambrose R; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Eng VV; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Microbiology, Monash University, Clayton, VIC, Australia., Chiou S; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Meng Y; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Frank D; The Walter and Eliza Hall Institute, Parkville, VIC, Australia., Tovey Crutchfield EC; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, Parkville, VIC, Australia., Patel KM; The Walter and Eliza Hall Institute, Parkville, VIC, Australia., Jacobsen AV; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Atkin-Smith GK; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Di Rago L; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Doerflinger M; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Horne CR; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Hall C; The Walter and Eliza Hall Institute, Parkville, VIC, Australia., Young SN; The Walter and Eliza Hall Institute, Parkville, VIC, Australia., Cook M; Centre for Personalised Immunology and Canberra Clinical Genomics, Australian National University, Canberra, ACT, Australia.; Cambridge Institute for Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK., Athanasopoulos V; Department of Immunology and Infection, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Vinuesa CG; Centre for Personalised Immunology and Canberra Clinical Genomics, Australian National University, Canberra, ACT, Australia.; Department of Immunology and Infection, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; The Francis Crick Institute, London, UK.; University College London, London, UK.; China Australia Centre for Personalized Immunology (CACPI), Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China., Lawlor KE; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia., Wicks IP; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Ebert G; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany., Ng AP; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.; Clinical Haematology Department, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, VIC, Australia., Slade CA; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.; Department of Clinical Immunology & Allergy, Royal Melbourne Hospital, Parkville, VIC, Australia., Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.; Department of Microbiology, Monash University, Clayton, VIC, Australia., Samson AL; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Silke J; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Murphy JM; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia., Hildebrand JM; The Walter and Eliza Hall Institute, Parkville, VIC, Australia. jhildebrand@wehi.edu.au.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia. jhildebrand@wehi.edu.au.
Source: Nature communications [Nat Commun] 2023 Sep 28; Vol. 14 (1), pp. 6046. Date of Electronic Publication: 2023 Sep 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
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  Data: <searchLink fieldCode="AU" term="%22Garnish+SE%22">Garnish SE</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Martin+KR%22">Martin KR</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kauppi+M%22">Kauppi M</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Jackson+VE%22">Jackson VE</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ambrose+R%22">Ambrose R</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Eng+VV%22">Eng VV</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Microbiology, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chiou+S%22">Chiou S</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Meng+Y%22">Meng Y</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Frank+D%22">Frank D</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Tovey+Crutchfield+EC%22">Tovey Crutchfield EC</searchLink>; 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The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Horne+CR%22">Horne CR</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hall+C%22">Hall C</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Young+SN%22">Young SN</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cook+M%22">Cook M</searchLink>; Centre for Personalised Immunology and Canberra Clinical Genomics, Australian National University, Canberra, ACT, Australia.; Cambridge Institute for Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Athanasopoulos+V%22">Athanasopoulos V</searchLink>; Department of Immunology and Infection, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.<br /><searchLink fieldCode="AU" term="%22Vinuesa+CG%22">Vinuesa CG</searchLink>; Centre for Personalised Immunology and Canberra Clinical Genomics, Australian National University, Canberra, ACT, Australia.; Department of Immunology and Infection, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; The Francis Crick Institute, London, UK.; University College London, London, UK.; China Australia Centre for Personalized Immunology (CACPI), Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lawlor+KE%22">Lawlor KE</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wicks+IP%22">Wicks IP</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ebert+G%22">Ebert G</searchLink>; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ng+AP%22">Ng AP</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.; Clinical Haematology Department, The Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Slade+CA%22">Slade CA</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.; Department of Clinical Immunology & Allergy, Royal Melbourne Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pearson+JS%22">Pearson JS</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.; Department of Microbiology, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Samson+AL%22">Samson AL</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Silke+J%22">Silke J</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Murphy+JM%22">Murphy JM</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hildebrand+JM%22">Hildebrand JM</searchLink>; The Walter and Eliza Hall Institute, Parkville, VIC, Australia. jhildebrand@wehi.edu.au.; University of Melbourne, Department of Medical Biology, Parkville, VIC, Australia. jhildebrand@wehi.edu.au.
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