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An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.

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Title: An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Authors: Cui G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Botuyan MV; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Drané P; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Hu Q; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Bragantini B; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Thompson JR; The Hormel Institute, University of Minnesota, Austin, MN, USA., Schuller DJ; Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY, USA., Detappe A; Institut de Cancérologie Strasbourg Europe, Strasbourg, France., Perfetti MT; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., James LI; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Frye SV; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Chowdhury D; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. mer.georges@mayo.edu.; Department of Cancer Biology, Mayo Clinic, Rochester, MN, USA. mer.georges@mayo.edu.
Source: Nature communications [Nat Commun] 2023 Sep 29; Vol. 14 (1), pp. 6091. Date of Electronic Publication: 2023 Sep 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Cui+G%22">Cui G</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Botuyan+MV%22">Botuyan MV</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Drané+P%22">Drané P</searchLink>; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+Q%22">Hu Q</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Bragantini+B%22">Bragantini B</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+JR%22">Thompson JR</searchLink>; The Hormel Institute, University of Minnesota, Austin, MN, USA.<br /><searchLink fieldCode="AU" term="%22Schuller+DJ%22">Schuller DJ</searchLink>; Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Detappe+A%22">Detappe A</searchLink>; Institut de Cancérologie Strasbourg Europe, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Perfetti+MT%22">Perfetti MT</searchLink>; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22James+LI%22">James LI</searchLink>; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Frye+SV%22">Frye SV</searchLink>; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chowdhury+D%22">Chowdhury D</searchLink>; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mer+G%22">Mer G</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. mer.georges@mayo.edu.; Department of Cancer Biology, Mayo Clinic, Rochester, MN, USA. mer.georges@mayo.edu.
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