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Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation.

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Title: Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation.
Authors: Nies AT; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tuebingen, Germany., König J; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Leuthold P; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany., Damme K; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany., Winter S; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany., Haag M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany., Masuda S; Department of Clinical Pharmacology & Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan., Kruck S; Department of Urology, University Hospital Tuebingen, Germany., Daniel H; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany., Spanier B; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany., Fromm MF; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Bedke J; Department of Urology, University Hospital Tuebingen, Germany., Inui KI; Kyoto Pharmaceutical University, Kyoto, Japan., Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tuebingen, Germany; Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tuebingen, Germany. Electronic address: matthias.schwab@ikp-stuttgart.de., Schaeffeler E; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tuebingen, Germany.
Source: Pharmacological research [Pharmacol Res] 2023 Oct; Vol. 196, pp. 106941. Date of Electronic Publication: 2023 Sep 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Nies+AT%22">Nies AT</searchLink>; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22König+J%22">König J</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Leuthold+P%22">Leuthold P</searchLink>; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Damme+K%22">Damme K</searchLink>; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Winter+S%22">Winter S</searchLink>; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Haag+M%22">Haag M</searchLink>; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Masuda+S%22">Masuda S</searchLink>; Department of Clinical Pharmacology & Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan; Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan.<br /><searchLink fieldCode="AU" term="%22Kruck+S%22">Kruck S</searchLink>; Department of Urology, University Hospital Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Daniel+H%22">Daniel H</searchLink>; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Spanier+B%22">Spanier B</searchLink>; TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Fromm+MF%22">Fromm MF</searchLink>; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Bedke+J%22">Bedke J</searchLink>; Department of Urology, University Hospital Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Inui+KI%22">Inui KI</searchLink>; Kyoto Pharmaceutical University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Schwab+M%22">Schwab M</searchLink>; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tuebingen, Germany; Departments of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tuebingen, Germany. Electronic address: matthias.schwab@ikp-stuttgart.de.<br /><searchLink fieldCode="AU" term="%22Schaeffeler+E%22">Schaeffeler E</searchLink>; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany, and University of Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tuebingen, Germany.
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